SOX7 - SRY-box transcription factor 7 Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 83595

About SOX7

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:10,723,768-10,730,511 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 203 orthologues and 20 paralogues. Broad expression in placenta (RPKM 14.9), lung (RPKM 8.3) and 19 other tissues.

Summary

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with Other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. [provided by RefSeq, Jul 2008]

SOX7 Products (1)

mRNA Protein Name
NM_031439.4 NP_113627.1 transcription factor SOX-7

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
19108950 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in endoderm formation IDA
IDA: Inferred from direct assay
18682240 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
19108950 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
19108950 GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
19108950 GOA
involved in regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
19108950 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytoplasm IDA
IDA: Inferred from direct assay
18819930 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18682240 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SOX7 Protein Structure

HMG_box

HMG_box: HMG (high mobility group) box (45 - 113)

Sox17_18_mid

Sox17_18_mid: Sox 17/18 central domain (177 - 387)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
Protein Preferred Names Protein Names

transcription factor SOX-7

  • SRY (sex determining region Y)-box 7

SOX7 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
SOX7 Q9BT81 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra
SOX7 Q9BT81 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra
SOX7 Q9BT81 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra
SOX7 Q9BT81 GLRX3 Homo sapiens O76003
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Hypotrichosis-Lymphedema-Telangiectasia Syndrome

  • HLTS

  • Hypotrichosis Lymphedema Telangiectasia Syndrome

  • Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome

  • Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome

  • Glomerulonephritis With Sparse Hair And Telangiectases

  • Telangiectatic Membranoproliferative Glomerulonephritis

  • HLTRS

  • Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome

  • Hlt-Renal Defect Syndrome

  • Glomerulonephritis Sparse Hair Telangiectases
Chromosome 2q31.2 Deletion Syndrome
Diaphragm Disease

  • Abnormality Of The Diaphragm

  • Disease Of Diaphragm

  • Diaphragmatic Disorder

  • Disorder Of Diaphragm
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diaphragmatic Hernia, Congenital

  • Congenital Diaphragmatic Hernia

  • Diaphragmatic Hernia

  • Cdh

  • Congenital Diaphragmatic Defect

  • Hernia, Diaphragmatic

  • Dih

  • Hernia, Congenital Diaphragmatic

  • Hcd

  • Diaphragmatic Defect, Congenital

  • Diaphragm, Unilateral Agenesis Of

  • Hemidiaphragm, Agenesis Of

  • Diaphragmatic Hernia 1

  • Agenesis Of Hemidiaphragm

  • Unilateral Agenesis Of Diaphragm

  • Hernia Diaphragmatic

  • Hernia Diaphragmatic Congenital

  • Hernia, Diaphragmatic, Type 1

  • Hiatus Hernia

  • Oesophageal Hiatus Hernia

  • Paraoesophageal Hernia

  • Sliding Hiatus Hernia

  • Congenital Diaphragm Hernia

  • Congenital Diaphragm Defect With Hernia

  • Gross Congenital Diaphragm Defect
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-116940 Sm4 Inhibitor 99.01% Unkown
HY-RS13598 SOX7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus SOX7 MGD MGI:98369
Rattus norvegicus SOX7 RGD RGD:1310038
Others SOX7 NCBI