LRCH3 - leucine rich repeats and calponin homology domain containing 3 Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 84859

About LRCH3

This gene has 19 transcripts (splice variants), 199 orthologues and 31 paralogues. Ubiquitous expression in ovary (RPKM 3.8), lymph node (RPKM 3.6) and 25 other tissues.

Summary

Involved in septin Cytoskeleton organization. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

LRCH3 Products (7)

mRNA Protein Name
NM_001363887.1 NP_001350816.1 DISP complex protein LRCH3 isoform 1
NM_001365715.1 NP_001352644.1 DISP complex protein LRCH3 isoform 3
NM_001365716.1 NP_001352645.1 DISP complex protein LRCH3 isoform 4
NM_001365717.1 NP_001352646.1 DISP complex protein LRCH3 isoform 5
NM_001365718.1 NP_001352647.1 DISP complex protein LRCH3 isoform 6
NM_001365719.2 NP_001352648.1 DISP complex protein LRCH3 isoform 7
NM_032773.4 NP_116162.1 DISP complex protein LRCH3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
24255178 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in septin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
29467281 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRCH3 Protein Structure

LRR_1

LRR_1: Leucine Rich Repeat (130 - 150)

LRR_8

LRR_8: Leucine rich repeat (152 - 208)

CH

CH: Calponin homology (CH) domain (662 - 762)

  • 0
  • 200
  • 400
  • 600
  • 777 a.a.
Protein Preferred Names Protein Names

DISP complex protein LRCH3

  • leucine-rich repeat and calponin homology domain-containing protein 3

LRCH3 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
LRCH3 Q96II8 DOCK8 Homo sapiens Q8NF50-2
Y2H Prey Pooling
25416956
Intra
LRCH3 Q96II8 DOCK8 Homo sapiens Q8NF50-2
Validated Y2H
25416956
Intra
LRCH3 Q96II8 DOCK8 Homo sapiens Q8NF50-2
Y2H Array
25416956
Intra
LRCH3 Q96II8 MYO6 Homo sapiens Q9UM54-1
Y2H
29467281
Intra
LRCH3 Q96II8 DOCK7 Homo sapiens Q96N67
Anti Tag CoIP
33961781
Intra
LRCH3 Q96II8 DOCK7 Homo sapiens Q96N67
Anti Tag CoIP
24255178
Intra
LRCH3 Q96II8 DOCK7 Homo sapiens Q96N67
Anti Tag CoIP
29467281
Intra
LRCH3 Q96II8 DOCK7 Homo sapiens Q96N67
IF
29467281
Intra
LRCH3 Q96II8 MYO6 Homo sapiens Q9UM54
Anti Tag CoIP
29467281
Intra
LRCH3 Q96II8 MYO6 Homo sapiens Q9UM54
BioID
29467281
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Cardiomyopathy, Familial Hypertrophic, 2

  • Hypertrophic Cardiomyopathy 2

  • CMH2

  • Cardiomyopathy, Hypertrophic, 2

  • Cardiomyopathy Familial Hypertrophic 2

  • Cardiomyopathy, Familial Hypertrophic 2

  • Cardiomyopathy, Hypertrophic, Familial, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS07779 LRCH3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus LRCH3 RGD RGD:1306200
Mus musculus LRCH3 MGD MGI:1917394
Felis catus LRCH3 VGNC VGNC:63274
Bos taurus LRCH3 VGNC VGNC:30973
Macaca mulatta LRCH3 VGNC VGNC:74382
Canis familiaris LRCH3 VGNC VGNC:53078
Others LRCH3 NCBI