TTLL4 - tubulin tyrosine ligase like 4 Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 9654

About TTLL4

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,710,835-218,759,724 (from NCBI)

This gene has 21 transcripts (splice variants), 180 orthologues and 12 paralogues. Broad expression in testis (RPKM 10.4), brain (RPKM 3.1) and 24 other tissues.

Summary

Predicted to enable tubulin binding activity and tubulin-glutamic acid Ligase activity. Predicted to be involved in microtubule Cytoskeleton organization and protein polyglutamylation. Predicted to act upstream of or within regulation of blastocyst development. Predicted to be located in cytosol. Predicted to be active in cilium. [provided by Alliance of Genome Resources, Apr 2022]

TTLL4 Products (1)

mRNA Protein Name
NM_014640.5 NP_055455.3 tubulin monoglutamylase TTLL4

TTLL4 Protein Structure

TTL

TTL: Tubulin-tyrosine ligase family (655 - 940)

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  • 1199 a.a.
Protein Preferred Names Protein Names

tubulin monoglutamylase TTLL4

  • protein monoglutamylase TTLL4

関連疾患

Diseases Alias
Nephronophthisis 2

  • NPHP2

  • Nph2

  • Nephronophthisis 2, Infantile

  • Infantile Nephronophthisis 2

  • Infantile Nephronophthisis

  • Nephronophthisis, Type 2
Fundus Dystrophy

  • Retinal Dystrophy

  • Retinal Dystrophies

  • Dystrophy, Retinal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS15231 TTLL4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Canis familiaris TTLL4 VGNC VGNC:54382
Bos taurus TTLL4 VGNC VGNC:36492
Felis catus TTLL4 VGNC VGNC:80394
Rattus norvegicus TTLL4 RGD RGD:1594742
Mus musculus TTLL4 MGD MGI:1914784
Macaca mulatta TTLL4 VGNC VGNC:79758
Others TTLL4 NCBI