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VGLL4 - vestigial like family member 4 Gene

Also Known as VGL-4

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 9686

About VGLL4

Cytogenetic location: 3p25.3-p25.2 Genomic coordinates (GRCh38): 3:11,556,067-11,721,815 (from NCBI)

This gene has 18 transcripts (splice variants) and 267 orthologues. Ubiquitous expression in ovary (RPKM 26.1), thyroid (RPKM 18.5) and 25 other tissues.

Summary

Predicted to enable transcription coactivator binding activity. Involved in negative regulation of Wnt signaling pathway; negative regulation of cell growth; and negative regulation of hippo signaling. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

VGLL4 Products (6)

mRNA	Protein	Name
NM_001128219.3	NP_001121691.1	transcription cofactor vestigial-like protein 4 isoform a
NM_001128220.3	NP_001121692.1	transcription cofactor vestigial-like protein 4 isoform c
NM_001128221.3	NP_001121693.1	transcription cofactor vestigial-like protein 4 isoform d
NM_001284390.2	NP_001271319.1	transcription cofactor vestigial-like protein 4 isoform e
NM_001284391.1	NP_001271320.1	transcription cofactor vestigial-like protein 4 isoform f
NM_014667.4	NP_055482.2	transcription cofactor vestigial-like protein 4 isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	28051067	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	28051067	GOA
involved in negative regulation of hippo signaling	IDA IDA: Inferred from direct assay	28051067	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VGLL4 Protein Structure

VGLL4

0
100
200
290 a.a.

Protein Preferred Names	Protein Names
transcription cofactor vestigial-like protein 4	Vestigial-like 4

VGLL4 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	VGLL4	Q14135	TEAD3	Homo sapiens	Q99594	Validated Y2H	32296183
Intra	VGLL4	Q14135	TEAD3	Homo sapiens	Q99594	Anti Tag CoIP	33961781
Intra	VGLL4	Q14135	TEAD3	Homo sapiens	Q99594	Y2H Prey Pooling	32296183
Intra	VGLL4	Q14135	TEAD3	Homo sapiens	Q99594	Y2H Array	32296183
Intra	VGLL4	Q14135	TEAD4	Homo sapiens	Q15561	BLI	24525233
Intra	VGLL4	Q14135	TEAD4	Homo sapiens	Q15561	Anti Tag CoIP	33961781
Intra	VGLL4	Q14135	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950
Intra	VGLL4	Q14135	TERF2IP	Homo sapiens	Q9NYB0	BiFC	21044950
Intra	VGLL4	Q14135	TEAD2	Homo sapiens	Q15562-2	Validated Y2H	32296183
Intra	VGLL4	Q14135	TEAD2	Homo sapiens	Q15562-2	Y2H Array	32296183
Intra	VGLL4	Q14135	TEAD2	Homo sapiens	Q15562-2	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Sveinsson Chorioretinal Atrophy	SCRA Atrophia Areata Helicoid Peripapillary Chorioretinal Degeneration Hpcd Aa Peripapillary Chorioretinal Degeneration, Icelandic Type Helicoidal Peripapillary Chorioretinal Degeneration Atrophy, Chorioretinal, Sveinsson
Cerebral Cavernous Malformations	Cerebral Cavernous Malformation Cavernous Malformations Of Cns And Retina Cerebral Cavernous Malformation 1 Cavernous Angiomatous Malformations Cerebral Capillary Malformations CCM Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations Familial Cavernous Angioma Cavernous Angioma Familial Cerebral Cavernous Malformation Cerebral Cavernous Malformations 1 Cavernous Angioma, Familial Cam Cerebral Cavernous Malformations-1 Cavernoma Central Nervous System Cavernous Hemangioma Cerebral Cavernous Hemangioma Familial Cavernous Hemangioma Familial Cavernous Malformation Familial Cerebral Cavernous Angioma Intracerebral Cavernous Hemangioma CCM1 Cavernous Hemangioma Of The Brain Cerebral Cavernoma Cerebral Cavernous Malformations, Type 1 Hemangioma, Cavernous, Central Nervous System Hemangioma, Cavernous Angioma, Cavernous
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-137479	TEAD-IN-1	Inhibitor	99.43%	Unkown
HY-RS15647	VGLL4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22913	Vgll4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29427	Vgll4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	VGLL4	VGNC	VGNC:36793
Canis familiaris	VGLL4	VGNC	VGNC:48260
Macaca mulatta	VGLL4	VGNC	VGNC:79755
Rattus norvegicus	VGLL4	RGD	RGD:1311653
Mus musculus	VGLL4	MGD	MGI:2652840
Felis catus	VGLL4	VGNC	VGNC:80753
Others	VGLL4	NCBI