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製品番号: HY-P12384

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GPQ-W

GPQ-W is a synthetic peptide containing a type I collagen-derived protease cleavage site and serves as a protease-degradable crosslinker in PEG-4MAL/RGD synthetic hydrogels. GPQ-W is cleaved by cell-secreted matrix metalloproteinases, enabling cell-mediated matrix degradation and remodeling. GPQ-W, as a PEG-4MAL hydrogel component, supports the in vitro generation of human intestinal and lung organoids from hPSC-derived spheroids, long-term survival of intestinal organoids, normal epithelial cyst polarity, and lumen formation at the rapidly degrading crosslinker threshold level. GPQ-W can be used in research related to intestinal mucosal injury and organoid transplantation.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 287184-75-2
分子式: C₆₈H₁₀₅N₂₅O₂₃S₂
分子量:1704.85

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

GPQ-W 構造式

CAS 番号: 287184-75-2

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

GPQ-W (15.57 mM; incubated at 37 °C for 20 min) is prepared into a crosslinker solution, which can be used to form PEG-4MAL hydrogels^[1].
GPQ-W-crosslinked PEG-4MAL hydrogels support the in vitro generation of HIOs from hPSC-derived intestinal spheroids, form lumens within 4-5 d, and can maintain HIOs for up to approximately 21 d with passaging for three generations^[1].
GPQ-W cross-linked 3D FRC cultures enhance human tonsillar B/T cell survival and antigen-specific B cell responses, and promote GC/ASC differentiation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

CAS 番号 287184-75-2
分子量 1704.85
分子式 C₆₈H₁₀₅N₂₅O₂₃S₂
SMILES

O=C(N[C@@H](CS)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(NCC(N1[C@@H](CCC1)C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CS)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN
配列

Gly-Cys-Arg-Asp-Gly-Pro-Gln-Gly-Ile-Trp-Gly-Gln-Asp-Arg-Cys-Gly
シーケンスの短縮

GCRDGPQGIWGQDRCG
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Cruz-Acuña R, et al. PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery. Nat Protoc. 2018 Sep;13(9):2102-2119. doi: 10.1038/s41596-018-0036-3. Erratum in: Nat Protoc. 2019 Jul;14(7):2258. [Content Brief]

[2]. Braham MVJ, et al. Enhanced Human Antigen-Specific B Cell Responses Using In Vitro 3D Tonsil Cultures Containing Stromal Cells. Advanced healthcare materials. 2026 Jun;15(22):e04886.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度濃度

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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