Herbimycin C
Herbimycin C is a bacterial metabolite originally isolated from S. hygroscopicus. It is cytotoxic to HeLa and Ehrlich cells (IC50s=7.3 and 1.2 μg/mL, respectively).
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- CAS 番号: 91700-92-4
- 分子式: C29H40N2O9
- 分子量:560.64
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
3.01 μM
Compound: 2
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Antiproliferative activity against human A2780 assessed as reduction in cell viability measured after 96 hrs by MTT assay
Antiproliferative activity against human A2780 assessed as reduction in cell viability measured after 96 hrs by MTT assay
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[PMID: 27476419] |
| A-375 | IC50 |
2.43 μM
Compound: 2
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Antiproliferative activity against human A375 assessed as reduction in cell viability measured after 96 hrs by MTT assay
Antiproliferative activity against human A375 assessed as reduction in cell viability measured after 96 hrs by MTT assay
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[PMID: 27476419] |
| BGC-823 | IC50 |
3.99 μM
Compound: 2
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Antiproliferative activity against human BGC823 assessed as reduction in cell viability measured after 96 hrs by MTT assay
Antiproliferative activity against human BGC823 assessed as reduction in cell viability measured after 96 hrs by MTT assay
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[PMID: 27476419] |
| HCT-116 | IC50 |
9.39 μM
Compound: 2
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Antiproliferative activity against human HCT116 assessed as reduction in cell viability measured after 96 hrs by MTT assay
Antiproliferative activity against human HCT116 assessed as reduction in cell viability measured after 96 hrs by MTT assay
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[PMID: 27476419] |
| MCF7 | IC50 |
5.07 μM
Compound: 2
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Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 96 hrs by MTT assay
Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 96 hrs by MTT assay
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[PMID: 27476419] |
| SW1990 | IC50 |
8.62 μM
Compound: 2
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Antiproliferative activity against human SW1990 assessed as reduction in cell viability measured after 96 hrs by MTT assay
Antiproliferative activity against human SW1990 assessed as reduction in cell viability measured after 96 hrs by MTT assay
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[PMID: 27476419] |
化学情報
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CAS 番号 91700-92-4
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分子量 560.64
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分子式 C29H40N2O9
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SMILES
CO[C@@]1([H])C(C(C(NC(/C(C)=C/C=C/[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@@H](O)[C@@H](OC)C[C@@H]1C)=O)=C2)=O)=CC2=O
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別名
Antibiotic TAN 420D
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Herbimycin C 関連分類
HY-126699 関連分類
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