ID110460001
ID110460001 is a full agonist of μ-opioid receptor and an agonist of δ-opioid receptor. ID110460001 exhibits high intrinsic efficacy for G protein pathway activation of μ-opioid receptor, and this property is not affected by the reduction in receptor quantity. ID110460001 acts only as a very weak partial agonist in the β-arrestin-2 pathway of both receptors, and binds to μ-opioid receptor via a specific mode. The efficacy of ID110460001 in the G protein pathway of δ-opioid receptor is sensitive to changes in receptor quantity. ID110460001 can be used in pain-related research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1110883-26-5
- 分子式: C20H24N2O3
- 分子量:340.42
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
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μ Opioid Receptor/MOR |
δ Opioid Receptor/DOR |
Arrestin-2/β-Arrestin 1 |
体外実験
ID110460001 (eight-point concentration gradients; 20 min pre-incubation with irreversible antagonists) acts as a full agonist for the G protein pathway and a very weak partial agonist for the β-arrestin-2 pathway at both OPRM-overexpressing and OPRD-overexpressing HEK-293 cells, with high intrinsic efficacy at OPRM as demonstrated by maintained Emax under reduced receptor population conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
化学情報
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CAS 番号 1110883-26-5
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分子量 340.42
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分子式 C20H24N2O3
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SMILES
O=C(NCC(C=1C=CC=CC1)N(C)C)CC2=CC=C3OCCOC3=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ID110460001 関連分類
HY-W399025 関連分類
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