JAK2-IN-22
JAK2-IN-22 is a bicyclic urea compound with potent binding inhibitory activity against wild-type and V617F mutant JH2 kinases (IC50 ≤ 10 nM). JAK2-IN-22 can be used in research related to various diseases including cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3057053-13-8
- 分子式: C33H34FN7O5
- 分子量:627.67
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
JAK2wt |
JAK2V617F |
体外実験
JAK2-IN-22 (Example 2) exhibits potent binding inhibitory activity against wild-type/V617F mutant JH2 (IC50 ≤ 10 nM), but shows almost no binding inhibitory effect on JH1 and no enzymatic inhibitory activity against V617F JAK2 (IC50 > 1000 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
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CAS 番号 3057053-13-8
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分子量 627.67
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分子式 C33H34FN7O5
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SMILES
O=C1N([C@H]2C[C@@H](CC2)NC(OC)=O)C3=CC(NC4=CC(C5=CC(C#N)=CC=C5)=CC(NC(C6(CCOCC6)F)=O)=C4)=NC=C3N1C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
JAK2-IN-22 関連分類
HY-188001 関連分類
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