KU-0058684
Based on 1 Customer Validation
KU-0058684 is a potent PARP inhibitor, with an IC50 of 3.2 nM for PARP-1. KU-0058684 significantly reduces DNA double strand break (DSB) repair.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.54%
- CAS 番号: 623578-11-0
- 分子式: C19H14FN3O3
- 分子量:351.33
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
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PARP-1 3.2 nM (IC50) |
化学情報
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CAS 番号 623578-11-0
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性状 Solid
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分子量 351.33
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分子式 C19H14FN3O3
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Color White to off-white
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SMILES
O=C(N1C2=CC(CC3=NNC(C4=C3C=CC=C4)=O)=CC=C2F)CCC1=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : ≥ 100 mg/mL (284.63 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Mitchell J, et al. Poly(ADP-Ribose) polymerase-1 and DNA-dependent protein kinase have equivalent roles in double strand break repair following ionizing radiation. Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1520-7. [Content Brief]
[2]. McCabe N, et al. BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency. Cancer Biol Ther. 2005 Sep;4(9):934-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8463 mL | 14.2316 mL | 28.4633 mL | 71.1582 mL |
| 5 mM | 0.5693 mL | 2.8463 mL | 5.6927 mL | 14.2316 mL | |
| 10 mM | 0.2846 mL | 1.4232 mL | 2.8463 mL | 7.1158 mL | |
| 15 mM | 0.1898 mL | 0.9488 mL | 1.8976 mL | 4.7439 mL | |
| 20 mM | 0.1423 mL | 0.7116 mL | 1.4232 mL | 3.5579 mL | |
| 25 mM | 0.1139 mL | 0.5693 mL | 1.1385 mL | 2.8463 mL | |
| 30 mM | 0.0949 mL | 0.4744 mL | 0.9488 mL | 2.3719 mL | |
| 40 mM | 0.0712 mL | 0.3558 mL | 0.7116 mL | 1.7790 mL | |
| 50 mM | 0.0569 mL | 0.2846 mL | 0.5693 mL | 1.4232 mL | |
| 60 mM | 0.0474 mL | 0.2372 mL | 0.4744 mL | 1.1860 mL | |
| 80 mM | 0.0356 mL | 0.1779 mL | 0.3558 mL | 0.8895 mL | |
| 100 mM | 0.0285 mL | 0.1423 mL | 0.2846 mL | 0.7116 mL |
KU-0058684 関連分類
HY-123232 関連分類
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