L-AP4 monohydrate
Based on 1 publication(s) in Google Scholar
L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively.
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- 純度: 99.0%
- CAS 番号: 2247534-79-6
- 分子式: C4H12NO6P
- 分子量:201.11
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保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 L-AP4 monohydrate
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生物活性
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mGlu4 0.13 μM (EC50) |
mGlu8 0.29 μM (EC50) |
mGlu6 1.0 μM (EC50) |
mGlu7 249 μM (EC50) |
Intrathecal injection of 30 μg of L-AP4 does not significantly alter the paw withdrawal latency in these normal rats[2].
Topical application of 5 to 50 μM L-AP4 to the spinal cord significantly inhibited the evoked response of neurons to touch, pressure, pinch, and von Frey filaments in a concentration-dependent fashion[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats.[2]
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Dosage:5-30 μg.
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Administration:Intrathecal inhection 4-5 days.
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Result:Dose-dependently increased paw withdrawal threshold.
化学情報
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CAS 番号 2247534-79-6
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性状 Solid
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分子量 201.11
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分子式 C4H12NO6P
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Color White to off-white
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SMILES
O=C(O)[C@@H](N)CCP(O)(O)=O.O
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別名
L-APB monohydrate
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Biochem Biophys Res Commun
2020 Dec 17;533(4):1393-1399. PMID: 33092792
溶剤 & 溶解度
DMSO : 10 mg/mL (49.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Selvam C, et al. Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. J Med Chem. 2018 Mar 8;61(5):1969-1989. [Content Brief]
[2]. Chen SR, et al. Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured Rats. J Pharmacol Exp Ther. 2005 Jan;312(1):120-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.9724 mL | 24.8620 mL | 49.7240 mL | 124.3101 mL |
| 5 mM | 0.9945 mL | 4.9724 mL | 9.9448 mL | 24.8620 mL | |
| 10 mM | 0.4972 mL | 2.4862 mL | 4.9724 mL | 12.4310 mL | |
| 15 mM | 0.3315 mL | 1.6575 mL | 3.3149 mL | 8.2873 mL | |
| 20 mM | 0.2486 mL | 1.2431 mL | 2.4862 mL | 6.2155 mL | |
| 25 mM | 0.1989 mL | 0.9945 mL | 1.9890 mL | 4.9724 mL | |
| 30 mM | 0.1657 mL | 0.8287 mL | 1.6575 mL | 4.1437 mL | |
| 40 mM | 0.1243 mL | 0.6216 mL | 1.2431 mL | 3.1078 mL |
L-AP4 monohydrate 関連分類
HY-100781B 関連分類
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