PDE1-IN-7
PDE1-IN-7 (Compound 13h) is a selective inhibitor of bPDE1 (IC50= 10 nM). PDE1-IN-7 exhibits significant anti-fibrotic effects in a BDL-induced liver fibrosis rat model. PDE1-IN-7 can be used for research in liver fibrosis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3027833-49-1
- 分子式: C32H36F2N2O6S
- 分子量:614.70
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
PDEI 10 nM (IC50) |
体外実験
PDE1-IN-7 (2.5-20 μM; 48 h) effectively inhibits TGF-β-induced myofibroblast differentiation and proliferation in LX-2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human stellate cell LX-2
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Concentration:2.5, 5, 10, 20 μM
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Incubation Time:48 h
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Result:Dose-dependently reduced the elevated expression levels of fibronectin, collagen I, and α-SMA induced by TGF-β in LX-2 cells.
体内実験
Pharmacokinetic Analysis in SD rats[1]
| Route | Dose (mg/kg) | t1/2 (h) | Cmax (ng/mL) | AUC∞ (h)(ng·/mL) | Clobs (mL/min/kg) | MRT (h) | Vss_obs (mL/kg) |
| i.v. | 2.5 | 7.51 ± 0.64 | 25,006 ± 3082 | 6317 ± 839 | 6.56 ± 0.81 | 1.77 ± 0.07 | 698 ± 104 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:
化学情報
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CAS 番号 3027833-49-1
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分子量 614.70
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分子式 C32H36F2N2O6S
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SMILES
O=C1N(C(C(C(OCC2CCCCC2)=O)=C(N1)C)C3=CC=C(C(OCC4CC4)=C3)OC(F)F)C(SCC5=CC=CC=C5)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PDE1-IN-7 関連分類
HY-161506 関連分類
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