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製品番号: HY-12732

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PTC 725

PTC 725 is a potent, selective and orally active Hepatitis C Virus NS4B Protein inhibitor. PTC 725 inhibits HCV 1b (Con1) replicons.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1248581-07-8
分子式: C₂₃H₁₈F₄N₆O₂S
分子量:518.49

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

PTC 725 構造式

CAS 番号: 1248581-07-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

PTC 725 is a potent, selective and orally active Hepatitis C Virus NS4B Protein inhibitor. PTC 725 inhibits HCV 1b (Con1) replicons^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	EC₅₀	2 nM Compound: 4t, PTC725	Antiviral activity against HCV1b Con1 infected in human HuH7 cells assessed as inhibition of viral RNA replication by RT-PCR analysis Antiviral activity against HCV1b Con1 infected in human HuH7 cells assessed as inhibition of viral RNA replication by RT-PCR analysis	[PMID: 24266880]
Huh-7	IC₅₀	>10000 nM Compound: 4t, PTC725	Toxicity in human HuH7 cells assessed as effect on GAPDH mRNA level Toxicity in human HuH7 cells assessed as effect on GAPDH mRNA level	[PMID: 24266880]

体外実験

PTC 725 (0-1 µM; 3 days) inhibits HCV 1b (Con1) replicons with an EC₅₀ value of 1.7 nM and an EC₉₀ value of 9.6 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1248581-07-8
分子量 518.49
分子式 C₂₃H₁₈F₄N₆O₂S
SMILES

O=S(C1=CC=C(C(N2C3=NC=CC=N3)=C(C#N)C4=C2C=C(CC)C(F)=C4)N=C1)(N[C@@H](C)C(F)(F)F)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Gu Z, et al. Identification of PTC725, an orally bioavailable small molecule that selectively targets the hepatitis C Virus NS4B protein. Antimicrob Agents Chemother. 2013 Jul;57(7):3250-61. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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分子量分子量

希釈計算機

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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