country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-162847

Copy Link Print Information

S24–14

S24–14 is a potent antiosteoporosis agent. S24–14 inhibits osteoclastogenesis with an IC₅₀ value of 0.40 µM. S24–14 induces osteoblast differentiation. S24–14 suppresses bone loss.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2348566-35-6
分子式: C₁₉H₁₂N₂O₃S
分子量:348.38

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

S24–14 構造式

CAS 番号: 2348566-35-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

S24–14 is a potent antiosteoporosis agent. S24–14 inhibits osteoclastogenesis with an IC₅₀ value of 0.40 µM. S24–14 induces osteoblast differentiation. S24–14 suppresses bone loss^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BMDM	IC₅₀	0.4 μM Compound: S24-14	Anti-osteoclastogenic activity in M-CSF/RANKL-induced C57BL/6 mouse BMDM cells assessed as inhibition of M-CSF/RANKL-stimulated osteoclast differentiation measured after 5 days by TRAP staining based microscopic analysis Anti-osteoclastogenic activity in M-CSF/RANKL-induced C57BL/6 mouse BMDM cells assessed as inhibition of M-CSF/RANKL-stimulated osteoclast differentiation measured after 5 days by TRAP staining based microscopic analysis	[PMID: 39167391]
RAW264.7	CC₅₀	65.46 μM Compound: S24-14	Cytotoxicity against mouse RAW264.7 cells incubated for 48 hrs by CCK-8 assay Cytotoxicity against mouse RAW264.7 cells incubated for 48 hrs by CCK-8 assay	[PMID: 39167391]

化学情報

CAS 番号 2348566-35-6
分子量 348.38
分子式 C₁₉H₁₂N₂O₃S
SMILES

O=C(C1=C(C=C2C(C=CC=C2)=C1)C(NC3=NC4=CC=CC=C4S3)=O)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (279 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Huang D, et al. Discovery of Novel Antiosteoporosis Leads with Bone Resorption Inhibition and Anabolic Promotion through a Chemotype-Assembly Approach. J Med Chem. 2024 Sep 12;67(17):15311-15327. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ