Se-DMC
Based on 1 Customer Validation
Se-DMC attenuates complete Freund’s adjuvant (CFA)-induced inflammatory response, nociception, and neurobehavioral deficits in mice.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.88%
- CAS 番号: 2098850-81-6
- 分子式: C13H15ClO3Se
- 分子量:333.67
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保管条件:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
化学情報
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CAS 番号 2098850-81-6
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性状 Solid
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分子量 333.67
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分子式 C13H15ClO3Se
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Color Off-white to light yellow
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SMILES
O=C(C1=CC=C(C=C1)Cl)[Se]CC2OC(C)(C)OC2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶剤 & 溶解度
体外:
DMSO : 50 mg/mL (149.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
純度とドキュメンテーション
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データシート (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9970 mL | 14.9849 mL | 29.9697 mL | 74.9243 mL |
| 5 mM | 0.5994 mL | 2.9970 mL | 5.9939 mL | 14.9849 mL | |
| 10 mM | 0.2997 mL | 1.4985 mL | 2.9970 mL | 7.4924 mL | |
| 15 mM | 0.1998 mL | 0.9990 mL | 1.9980 mL | 4.9950 mL | |
| 20 mM | 0.1498 mL | 0.7492 mL | 1.4985 mL | 3.7462 mL | |
| 25 mM | 0.1199 mL | 0.5994 mL | 1.1988 mL | 2.9970 mL | |
| 30 mM | 0.0999 mL | 0.4995 mL | 0.9990 mL | 2.4975 mL | |
| 40 mM | 0.0749 mL | 0.3746 mL | 0.7492 mL | 1.8731 mL | |
| 50 mM | 0.0599 mL | 0.2997 mL | 0.5994 mL | 1.4985 mL | |
| 60 mM | 0.0499 mL | 0.2497 mL | 0.4995 mL | 1.2487 mL | |
| 80 mM | 0.0375 mL | 0.1873 mL | 0.3746 mL | 0.9366 mL | |
| 100 mM | 0.0300 mL | 0.1498 mL | 0.2997 mL | 0.7492 mL |
Se-DMC 関連分類
HY-139703 関連分類
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