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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
TLR4-MD-2 complex
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "TLR4-MD-2 complex" in MCE Product Catalog:
8
8 Publications Verification
製品番号: HY-N0795
CAS 番号: 20315-25-7
Category:
Plants Other Families Extract Flavonoids Functional Molecules Research of Health Products Phenols Polyphenols Disease Research Fields Inflammation/Immunology Biflavones
Target:
4
Category:
Cardiovascular Disease Alkaloids Plants Other Families Extract Disease Research Fields Isoquinoline Alkaloids
Target:
1
1 Cited Publications
製品番号: HY-N2345
CAS 番号: 23567-23-9
1
1 Cited Publications
製品番号: HY-W082785A
CAS 番号: 24533-47-9
L6H21, a Chalcone (HY-121054) derivative, is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor. L6H21 directly binds to MD-2 protein with a high affinity and low KD value of 33.3 μM, blocking the formation of the LPS-TLR4/MD-2 complex. L6H21 inhibits LPS-induced expression of TNF-α and IL-6 in RAW264.7 macrophages, with IC50 values of 6.58 and 8.59 μM, respectively. L6H21 can be used for alcoholic liver disease, metabolic disturbance and neuroinflammation research .
製品番号: HY-N0795R
CAS 番号: 20315-25-7
製品番号: HY-N2345R
CAS 番号: 23567-23-9
製品番号: HY-182034
GAP214 is a monosaccharide lipid A analogue and TLR4/MD-2 complex modulator.GAP214 binds to the TLR4/MD-2 complex via hydrophobic interactions, salt bridges, and hydrogen bonds, induces dimerization of the complex to initiate intracellular signaling cascades.GAP214 functions as an immunostimulant and vaccine adjuvant, enhances antigen-specific IgG antibody production in a mouse model .
製品番号: HY-P11580
Target:
研究分野:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
