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United States

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製品番号: HY-183266

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SR-A-174

SR-A-174 is a SARS-CoV-2 M^Pro inhibitor with an IC₅₀ of 0.060 μM. SR-A-174 has limited cell permeability and exhibits low activity in cells expressing M^Pro-eGFP, with a cellular IC₅₀ > 10 μM. SR-A-174 can be used in COVID-19-related research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₁₉H₁₂Cl₄N₂O
分子量:426.12

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

SR-A-174 構造式

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

SR-A-174 potently inhibits purified SARS-CoV-2 M_Pro with an IC₅₀ of 60 nM^[1].
SR-A-174 has limited cellular permeability and activity in HEK293T cells expressing MPro-eGFP, with a cellular IC₅₀ > 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

分子量 426.12
分子式 C₁₉H₁₂Cl₄N₂O
SMILES

O=C(N(C1=CC(C2=CC=CC(Cl)=C2)=CC=C1)C3=CC(Cl)=CN=C3)C(Cl)Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Atla S, et al. Nicotine-Inspired, De Novo-Designed SARS-CoV-2 Main Protease Inhibitors Reveal Unique Chemistry for Covalently Conjugating Both Cysteine and Histidine Residues in the Catalytic Dyad. J Am Chem Soc. 2026 Apr 29;148(16):16985-16995. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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