Ziapin 2
Based on 1 Customer Validation
Ziapin 2 is a membrane potential modulator and an intracellular membrane photoactuator. Ziapin 2 binds to the bacterial plasma membrane, and upon embedding into the lipid bilayer, undergoes trans-cis isomerization under 470 nm light irradiation, which triggers membrane potential hyperpolarization and induces the opening of ion channels on bacterial cell membranes. Through interactions with lipids, Ziapin 2 increases the overall flexibility of the lipid bilayer. Ziapin 2 can form photosensitive transmembrane dimers to trigger cellular signal transduction. Ziapin 2 is applicable to the research and regulation of bacterial electrical signal transduction and the regulation of membrane physical properties.
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- 純度: 99.9%
- CAS 番号: 2399497-60-8
- 分子式: C40H54Br2N6
- 分子量:778.70
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Ziapin 2 (0-80 μg/mL) binds to the cell surface of Bacillus subtilis, penetrates its cell membrane, and undergoes light-induced isomerization after embedding into the membrane. It depolarizes the resting membrane potential of wild-type Bacillus subtilis cells under dark conditions and induces reproducible light-induced hyperpolarization in wild-type Bacillus subtilis cells[1].
Ziapin 2 (5-25 μM; 283-310 K) globally softens the bilayer membrane of POPC liposomes and restores their dynamic flexibility at 283, 300, and 310 K[2].
Ziapin 2 (25 μM; 7 min at 37 °C) restores the membrane dynamics of intact HEK293 cells inhibited by DMSO at 300 K[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2399497-60-8
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性状 Solid
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分子量 778.70
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分子式 C40H54Br2N6
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Color Green to dark green
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SMILES
N(CCCCCC[N+]1=CC=CC=C1)(C2=CC=C(C=C2)/N=N/C3=CC=C(N4CCCCCC4)C=C3)CCCCCC[N+]5=CC=CC=C5.[Br-].[Br-]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 50 mg/mL (64.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. de Souza-Guerreiro TC, et al. Membrane Targeted Azobenzene Drives Optical Modulation of Bacterial Membrane Potential. Adv Sci (Weinh). 2023;10(8):e2205007. [Content Brief]
[2]. Paternò GM, et al. The Effect of an Intramembrane Light-Actuator on the Dynamics of Phospholipids in Model Membranes and Intact Cells. Langmuir. 2020;36(39):11517-11527. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2842 mL | 6.4210 mL | 12.8419 mL | 32.1048 mL |
| 5 mM | 0.2568 mL | 1.2842 mL | 2.5684 mL | 6.4210 mL | |
| 10 mM | 0.1284 mL | 0.6421 mL | 1.2842 mL | 3.2105 mL | |
| 15 mM | 0.0856 mL | 0.4281 mL | 0.8561 mL | 2.1403 mL | |
| 20 mM | 0.0642 mL | 0.3210 mL | 0.6421 mL | 1.6052 mL | |
| 25 mM | 0.0514 mL | 0.2568 mL | 0.5137 mL | 1.2842 mL | |
| 30 mM | 0.0428 mL | 0.2140 mL | 0.4281 mL | 1.0702 mL | |
| 40 mM | 0.0321 mL | 0.1605 mL | 0.3210 mL | 0.8026 mL | |
| 50 mM | 0.0257 mL | 0.1284 mL | 0.2568 mL | 0.6421 mL | |
| 60 mM | 0.0214 mL | 0.1070 mL | 0.2140 mL | 0.5351 mL |
Ziapin 2 関連分類
HY-156004 関連分類
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