MCM7 - minichromosome maintenance complex component 7 Gene

Also Known as MCM2; CDC47; P85MCM; P1CDC47; PNAS146; PPP1R104; P1.1-MCM3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4176

About MCM7

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,092,728-100,101,397 (from NCBI)

This gene has 13 transcripts (splice variants), 192 orthologues and 8 paralogues. Ubiquitous expression in bone marrow (RPKM 53.3), lymph node (RPKM 33.2) and 24 other tissues.

Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of Other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

MCM7 Products (3)

mRNA	Protein	Name
NM_001278595.2	NP_001265524.1	DNA replication licensing factor MCM7 isoform 2
NM_005916.5	NP_005907.3	DNA replication licensing factor MCM7 isoform 1
NM_182776.3	NP_877577.1	DNA replication licensing factor MCM7 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to DNA helicase activity	IDA IDA: Inferred from direct assay	9305914	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9705868	GOA
contributes to single-stranded DNA binding	IDA IDA: Inferred from direct assay	25661590	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	15538388	GOA
involved in DNA unwinding involved in DNA replication	IDA IDA: Inferred from direct assay	22474384	GOA
involved in regulation of phosphorylation	IMP IMP: Inferred from mutant phenotype	15538388	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of CMG complex	IPI IPI: Inferred from physical interaction	22474384	GOA
part of MCM complex	IDA IDA: Inferred from direct assay	17296731	GOA
part of MCM complex	IMP IMP: Inferred from mutant phenotype	15538388	GOA
part of MCM complex	IPI IPI: Inferred from physical interaction	22540012	GOA
NOT located in nucleolus	IDA IDA: Inferred from direct assay	21383955	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21383955	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MCM7 Protein Structure

MCM_N

MCM

0
200
400
600
719 a.a.

Protein Preferred Names	Protein Names
DNA replication licensing factor MCM7	CDC47 homolog

MCM7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MCM7	P33993	CCDC102B	Homo sapiens	Q68D86	Y2H Array	25416956
Intra	MCM7	P33993	CCDC102B	Homo sapiens	Q68D86	Y2H Prey Pooling	25416956
Intra	MCM7	P33993	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Prey Pooling	25416956
Intra	MCM7	P33993	UBQLN1	Homo sapiens	Q9UMX0-2	Validated Y2H	25416956
Intra	MCM7	P33993	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956
Intra	MCM7	P33993	MBIP	Homo sapiens	Q9NS73-5	Y2H Array	25416956
Cross	MCM7	P33993	E6	Human papillomavirus	P03126	Pull Down	9705868
Cross	MCM7	P33993	E6	Human papillomavirus	P03126	Pull Down	14675634
Cross	MCM7	P33993	E6	Human papillomavirus	P06463	Pull Down	9705868
Intra	MCM7	P33993	INTS6	Homo sapiens	Q9UL03	Anti Bait CoIP	17310990
Intra	MCM7	P33993	INTS6	Homo sapiens	Q9UL03	Pull Down	17310990
Intra	MCM7	P33993	KIFC3	Homo sapiens	Q9BVG8	Validated Y2H	25416956
Intra	MCM7	P33993	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	25416956
Intra	MCM7	P33993	MIPOL1	Homo sapiens	Q8TD10	Validated Y2H	25416956
Intra	MCM7	P33993	FKBP5	Homo sapiens	Q13451	Lumier	25036637
Intra	MCM7	P33993	SSRP1	Homo sapiens	Q08945	Anti Bait CoIP	16902406
Intra	MCM7	P33993	MCM5	Homo sapiens	P33992	Anti Tag CoIP	23764002
Intra	MCM7	P33993	MCM5	Homo sapiens	P33992	Protein Array	15232106
Intra	MCM7	P33993	MCM5	Homo sapiens	P33992	Anti Tag CoIP	33961781
Intra	MCM7	P33993	MCM2	Homo sapiens	P49736	Anti Bait CoIP	23764002
Intra	MCM7	P33993	MCM2	Homo sapiens	P49736	TAP	17296731
Intra	MCM7	P33993	MCM2	Homo sapiens	P49736	Anti Tag CoIP	23764002
Intra	MCM7	P33993	MCM6	Homo sapiens	Q14566	Anti Bait CoIP	23764002
Intra	MCM7	P33993	MCM6	Homo sapiens	Q14566	TAP	17296731
Intra	MCM7	P33993	MCM6	Homo sapiens	Q14566	Anti Bait CoIP	17296731
Intra	MCM7	P33993	MCM4	Homo sapiens	P33991	Anti Bait CoIP	23764002
Intra	MCM7	P33993	MCM4	Homo sapiens	P33991	Anti Bait CoIP	24299456
Intra	MCM7	P33993	MCM4	Homo sapiens	P33991	TAP	17296731
Intra	MCM7	P33993	MCM4	Homo sapiens	P33991	Anti Bait CoIP	17296731
Intra	MCM7	P33993	UBB	Homo sapiens	P0CG47	Anti Bait CoIP	17310990
Intra	MCM7	P33993	MYC	Homo sapiens	P01106	Y2H	17314511
Intra	MCM7	P33993	MYC	Homo sapiens	P01106	Anti Tag CoIP	17314511
Intra	MCM7	P33993	PLK1	Homo sapiens	P53350	Pull Down	15654075
Intra	MCM7	P33993	PLK1	Homo sapiens	P53350	CoIP	15654075
Intra	MCM7	P33993	CDKN1C	Homo sapiens	P49918	Y2H Array	16289477
Intra	MCM7	P33993	CDKN1C	Homo sapiens	P49918	Pull Down	16289477
Intra	MCM7	P33993	CDKN1B	Homo sapiens	P46527	Y2H Fragment Pooling	16289477
Intra	MCM7	P33993	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	MCM7	P33993	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	MCM7	P33993	LYN	Homo sapiens	P07948-1	Anti Tag CoIP	23764002
Intra	MCM7	P33993	LYN	Homo sapiens	P07948-1	Protein Kinase Assay	23764002
Cross	MCM7	P33993	E6	Human papillomavirus	P06462	Pull Down	9705868
Intra	MCM7	P33993	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	MCM7	P33993	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	MCM7	P33993	MCMBP	Homo sapiens	Q9BTE3	Anti Bait CoIP	17296731
Intra	MCM7	P33993	MCMBP	Homo sapiens	Q9BTE3	Y2H Array	25416956
Intra	MCM7	P33993	MCMBP	Homo sapiens	Q9BTE3	Y2H Prey Pooling	25416956
Intra	MCM7	P33993	MCMBP	Homo sapiens	Q9BTE3	Anti Bait CoIP	22540012
Intra	MCM7	P33993	MCMBP	Homo sapiens	Q9BTE3	TAP	17296731
Intra	MCM7	P33993	MCMBP	Homo sapiens	Q9BTE3	Anti Bait CoIP	24299456
Intra	MCM7	P33993	LYN	Homo sapiens	P07948	Anti Bait CoIP	23764002
Intra	MCM7	P33993	SMC1A	Homo sapiens	Q14683	Anti Tag CoIP	16438930
Intra	MCM7	P33993	SMC1A	Homo sapiens	Q14683	Anti Bait CoIP	16438930
Intra	MCM7	P33993	AK8	Homo sapiens	Q96MA6	Y2H Array	25416956
Intra	MCM7	P33993	AK8	Homo sapiens	Q96MA6	Y2H Array	31515488
Intra	MCM7	P33993	NAB2	Homo sapiens	Q15742	Validated Y2H	25416956
Intra	MCM7	P33993	SP2	Homo sapiens	Q02086	Y2H Prey Pooling	25416956
Intra	MCM7	P33993	MCMBP	Homo sapiens	Q9BTE3-2	Validated Y2H	26871637
Intra	MCM7	P33993	MCMBP	Homo sapiens	Q9BTE3-2	Validated Y2H	32296183
Intra	MCM7	P33993	MCMBP	Homo sapiens	Q9BTE3-2	Y2H Array	26871637
Intra	MCM7	P33993	MCMBP	Homo sapiens	Q9BTE3-2	Y2H Array	32296183
Intra	MCM7	P33993	MCMBP	Homo sapiens	Q9BTE3-2	Y2H Prey Pooling	26871637
Intra	MCM7	P33993	MCMBP	Homo sapiens	Q9BTE3-2	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

MCM7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82426	MCM7 Antibody (YA2171)	WB, ICC/IF, FC	Human

Related Diseases

Diseases	Alias
Meier-Gorlin Syndrome 1	Meier-Gorlin Syndrome Ear, Patella, Short Stature Syndrome Microtia, Absent Patellae, Micrognathia Syndrome MGORS1 Eps Ear-Patella-Short Stature Syndrome Ear Patella Short Stature Syndrome Microtia Absent Patellae Micrognathia Syndrome Meier-Gorlin Syndrome, Type 1
Follicular Adenoma	Follicular Adenoma Of The Thyroid Gland Thyroid Follicular Adenoma Adenoma Follicular Follicular Thyroid Adenoma Thyroid Gland Follicular Adenoma
Deafness, Autosomal Dominant 70	DFNA70 Autosomal Dominant Nonsyndromic Deafness 70 Autosomal Dominant Deafness 70 Deafness, Autosomal Dominant, 70
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Cervix Endometriosis	Endometriosis Of Cervix Cervical Endometriosis
Cardiomyopathy, Familial Hypertrophic, 6	Hypertrophic Cardiomyopathy 6 CMH6 Familial Hypertrophic Cardiomyopathy With Wolff-Parkinson-White Syndrome Cardiomyopathy, Familial Hypertrophic 6 Cardiomyopathy, Hypertrophic 6 Cardiomyopathy, Hypertrophic, Familial, Type 6
Meier-Gorlin Syndrome 5	MGORS5 Meier-Gorlin Syndrome, Type 5
Immunodeficiency 7	Tcr-Alpha-Beta-Positive T-Cell Deficiency IMD7 T-Cell Receptor-Alpha/Beta Deficiency Immunodeficiency 7, Tcr-Alpha/Beta Deficient Tcr-Alpha/Beta Deficiency Tcr-Alpha-Beta+ T-Cell Deficiency T-Cell Receptor Alpha/Beta Deficiency
Anus Cancer	Anal Cancer Anal Carcinoma Malignant Anal Tumor Cancer Of The Anus Malignant Neoplasm Of Anus Anus Neoplasms
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-180157	CDK2-IN-51	Inhibitor	/	Unkown
HY-RS08240	MCM7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21373	Mcm7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27892	Mcm7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MCM7	VGNC	VGNC:74686
Felis catus	MCM7	VGNC	VGNC:68218
Mus musculus	MCM7	MGD	MGI:1298398
Canis familiaris	MCM7	VGNC	VGNC:43087
Rattus norvegicus	MCM7	RGD	RGD:1303018
Bos taurus	MCM7	VGNC	VGNC:31313
Others	MCM7	NCBI