SP2 - Sp2 transcription factor Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6668

About SP2

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,896,236-47,931,731 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 4.3), spleen (RPKM 3.4) and 25 other tissues.

Summary

This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the Other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]

SP2 Products (1)

mRNA Protein Name
NM_003110.6 NP_003101.3 transcription factor Sp2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10744779 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10744779 GOA
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
17827154 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10744779 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SP2 Protein Structure

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (542 - 568)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (572 - 594)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 613 a.a.
Protein Preferred Names Protein Names

transcription factor Sp2

SP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SP2 Q02086 MCM7 Homo sapiens P33993
Validated Y2H
25416956
Intra
SP2 Q02086 MCM7 Homo sapiens P33993
Y2H Array
25416956
Intra
SP2 Q02086 FHL2 Homo sapiens Q14192
Validated Y2H
25416956
Intra
SP2 Q02086 BANP Homo sapiens Q8N9N5
Validated Y2H
25416956
Intra
SP2 Q02086 BANP Homo sapiens Q8N9N5
Y2H
21516116
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Basidiobolomycosis

  • Infection By Basidiobolus

  • Subcutaneous Mucoromycosis Due To Basidiobolus Ranarum
Dracunculiasis

  • Guinea Worm Disease

  • Dracontiasis

  • Dracunculosis

  • Infection By Dracunculus Medinensis

  • Gwd

  • Guinea Worm Infection

  • Parasitic Infection Caused By Dracunculus Medinensis

  • Medina Worm Disease

  • Medinensis

  • Medina Worm Infestation

  • Dracunculus Medinensis Infestation

  • Guinea Worm Infestation
Large Intestine Adenocarcinoma

  • Adenocarcinoma Of Large Intestine
Leukodystrophy, Hypomyelinating, 2

  • Pmld1

  • Hypomyelinating Leukodystrophy 2

  • HLD2

  • Pelizaeus-Merzbacher-Like Disease 1

  • Pelizaeus-Merzbacher-Like Disease Due To Gjc2 Mutation

  • Pelizaeus-Merzbacher-Like Disease Type 1

  • Pelizaeus-Merzbacher-Like Disease, 1

  • Pelizaeus Merzbacher Like Disease

  • Pelizaeus-Merzbacher-Like Disease

  • Pmld - Pelizaeus Merzbacher Like Disease

  • Pelizaeus-Merzbacher-Like Disease Autosomal Recessive Type 1

  • Pmldar1

  • Leukodystrophy, Hypomyelinating, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W353469 2-O-(α-D-Glucopyranosyl)glycerol (55% in water) 99.79% Unkown
HY-RS17158 Sp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-155176 SP-2-225 Inhibitor / Unkown
HY-137651A Sp-2'-F-dATP-αS tetrasodium / Unkown
HY-162258 AChE-IN-57 Inhibitor / Unkown
HY-173132 AKR1Cs-IN-1 / Unkown
HY-181066 ACE2-SP PPI-IN-1 Inhibitor / Unkown
HY-181853 NOTA-SP2A-PSMAL Ligand / Unkown
HY-N10208 Aspericin C / Unkown
HY-P10604 SP2 Inhibitor / Unkown
HY-P11599 NOTA-SP2A-FAPT Ligand / Unkown
HY-P5870 KTX-Sp2 Inhibitor / Unkown
HY-RS13605 SP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13635 SPATA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-137648A Sp-2'-O-Me-GTPαS tetrasodium / Unkown
HY-137649A Sp-2'-O-Me-CTPαS tetrasodium / Unkown
HY-176004 Rp-2'-Deoxyadenosine-5'-O-1-thiodiphosphate sodium / Unkown
HY-176005 Sp-2'-Deoxyadenosine-5'-O-1-thiodiphosphate sodium / Unkown
HY-N17267 2-Deoxy-20-hydroxyecdysone / Unkown
HY-RS23608 Sp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SP2 MGD MGI:1926162
Canis familiaris SP2 VGNC VGNC:46686
Felis catus SP2 VGNC VGNC:65586
Macaca mulatta SP2 VGNC VGNC:77845
Rattus norvegicus SP2 RGD RGD:1592078
Bos taurus SP2 VGNC VGNC:35153
Others SP2 NCBI