NOTA-SP2A-PSMAL
NOTA-SP₂A-PSMAL is a ligand targeting prostate-specific membrane antigen (PSMA), which competitively binds to PSMA with high binding affinity and an IC50 value of 0.26 nM. 18F-labeled NOTA-SP2A-PSMAL can be used as a PET tracer for positron emission tomography imaging of prostate cancer. NOTA-SP2A-PSMAL can be used for the synthesis and research of radionuclide conjugates (RDCs).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C55H79N11O25S2
- 分子量:1358.40
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Radionuclide-Drug Conjugates (RDCs) アイソフォーム固有の製品をすべて表示
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生物活性
NOTA-SP2A-PSMAL exhibits a binding energy of -10.2 Kcal/mol and forms equivalent hydrogen bonds with human PSMA protein compared to NOTA-PSMA-BCH, indicating comparable binding stability[1].
NOTA-SP₂A-PSMAL (10-12 to 10-5 M; 60 min) competitively binds to PSMA in 22Rv1 cells with high binding affinity (IC50 = 0.26 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 1358.40
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分子式 C55H79N11O25S2
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SMILES
OC(CC[C@H](C(O)=O)NC(NC(C(O)=O)CCCCNC(C(CC1=CC=C(C=CC=C2)C2=C1)NC([C@H]3CC[C@@H](CNC([C@@H](CC(O)=O)NC([C@H](CS(=O)(O)=O)NC([C@@H](CS(=O)(O)=O)NC(CN4CCN(CC(O)=O)CCN(CC(O)=O)CC4)=O)=O)=O)=O)CC3)=O)=O)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NOTA-SP2A-PSMAL 関連分類
HY-181853 関連分類
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