NOTA-SP2A-PSMAL
NOTA-SP₂A-PSMAL is a ligand targeting prostate-specific membrane antigen (PSMA), which competitively binds to PSMA with high binding affinity and an IC50 value of 0.26 nM. 18F-labeled NOTA-SP2A-PSMAL can be used as a PET tracer for positron emission tomography imaging of prostate cancer. NOTA-SP2A-PSMAL can be used for the synthesis and research of radionuclide conjugates (RDCs).
For research use only. We do not sell to patients.
- Formula: C55H79N11O25S2
- Molecular Weight:1358.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Radionuclide-Drug Conjugates (RDCs) Isoforms
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Biological Activity
NOTA-SP2A-PSMAL exhibits a binding energy of -10.2 Kcal/mol and forms equivalent hydrogen bonds with human PSMA protein compared to NOTA-PSMA-BCH, indicating comparable binding stability[1].
NOTA-SP₂A-PSMAL (10-12 to 10-5 M; 60 min) competitively binds to PSMA in 22Rv1 cells with high binding affinity (IC50 = 0.26 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 1358.40
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Formula C55H79N11O25S2
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SMILES
OC(CC[C@H](C(O)=O)NC(NC(C(O)=O)CCCCNC(C(CC1=CC=C(C=CC=C2)C2=C1)NC([C@H]3CC[C@@H](CNC([C@@H](CC(O)=O)NC([C@H](CS(=O)(O)=O)NC([C@@H](CS(=O)(O)=O)NC(CN4CCN(CC(O)=O)CCN(CC(O)=O)CC4)=O)=O)=O)=O)CC3)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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