NOTA-SP2A-PSMAL 

NOTA-SP₂A-PSMAL is a ligand targeting prostate-specific membrane antigen (PSMA), which competitively binds to PSMA with high binding affinity and an IC₅₀ value of 0.26 nM. ¹⁸F-labeled NOTA-SP₂A-PSMAL can be used as a PET tracer for positron emission tomography imaging of prostate cancer. NOTA-SP₂A-PSMAL can be used for the synthesis and research of radionuclide conjugates (RDCs)^[1].

NOTA-SP₂A-PSMAL exhibits a binding energy of -10.2 K_cal/mol and forms equivalent hydrogen bonds with human PSMA protein compared to NOTA-PSMA-BCH, indicating comparable binding stability^[1].
NOTA-SP₂A-PSMAL (10^-12 to 10^-5 M; 60 min) competitively binds to PSMA in 22Rv1 cells with high binding affinity (IC₅₀ = 0.26 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1358.40

C₅₅H₇₉N₁₁O₂₅S₂

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Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhang Y, et al. Design, Synthesis, and Preclinical Evaluation of a Novel [¹⁸F]AlF-Labeling Positron Emission Tomography Tracer Targeting Prostate-Specific Membrane Antigen. J Med Chem. 2026;69(4):4888-4899.  [Content Brief]