NOTA-SP2A-FAPT
NOTA-SP2A-FAPT is a fibroblast activation protein (FAP) ligand. NOTA-SP2A-FAPT can be adiolabeled and exhibits rapid renal excretion with fast kidney tissue clearance, accumulates rapidly in and retains high levels in FAP-positive tumor xenografts to enable clear tumor visualization. NOTA-SP2A-FAPT can be used as a tracer of cancer.
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- Fòrmula: C52H73F2N13O20S2
- Peso molecular:1302.34
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
NOTA-SP2A-FAPT exhibits high binding affinity to human FAP (binding energy: -9.0 kcal/mol) and moderate binding to human serum albumin (binding energy: -7.7 kcal/mol)[1].
NOTA-SP2A-FAPT competitively binds [18F]AlF-NOTA-FAPI-42 in A549-FAP cells with IC50 of 8.58 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 1302.34
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Fòrmula C52H73F2N13O20S2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NOTA-SP2A-FAPT Related Classifications
HY-P11599 Related Classifications
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