NOTA-SP2A-FAPT 

NOTA-SP2A-FAPT is a fibroblast activation protein (FAP) ligand. NOTA-SP2A-FAPT can be adiolabeled and exhibits rapid renal excretion with fast kidney tissue clearance, accumulates rapidly in and retains high levels in FAP-positive tumor xenografts to enable clear tumor visualization. NOTA-SP2A-FAPT can be used as a tracer of cancer^[1].

NOTA-SP2A-FAPT exhibits high binding affinity to human FAP (binding energy: -9.0 kcal/mol) and moderate binding to human serum albumin (binding energy: -7.7 kcal/mol)^[1].
NOTA-SP2A-FAPT competitively binds [¹⁸F]AlF-NOTA-FAPI-42 in A549-FAP cells with IC₅₀ of 8.58 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NOTA-SP2A-FAPT ([¹⁸F]AlF-NOTA-SP2A-FAPT) exhibits rapid renal clearance and high, specific, long-lasting tumor uptake in A549-FAP, U87MG, HCT-116, Capan-2 and BxPC-3 tumor-bearing mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1302.34

C₅₂H₇₃F₂N₁₃O₂₀S₂

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Tang G, et al. Design, Synthesis, and Evaluation of a Novel Positron Emission Tomography Tracer Targeting Fibroblast Activation Protein: From Bench to Bedside. J Med Chem. 2025;68(10):9973-9983.  [Content Brief]