Midodrine hydrochloride
Based on 1 Customer Validation
Midodrine hydrochloride ((±)-Midodrine hydrochloride) is a selective and orally active adrenergic α1-receptor agonist. Midodrine hydrochloride can strengthen vascular contraction. Midodrine hydrochloride can be used for the researches of cardiovascular disease, such as orthostatic hypotension.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.9%
- CAS No.: 43218-56-0
- 화학식: C12H19ClN2O4
- 분자량:290.74
-
보관:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
용액&용해도
- 순도&문서
- References
-
Help & FAQs
-
HY-13715
NorepinephrineAdrenergic Receptor Agonist -
HY-B0577
LatanoprostProstaglandin Receptor Agonist -
HY-17498
Atenololβ1-Adrenergic Receptor Blocker -
HY-103210
DSP-4 hydrochlorideAdrenergic Neurotoxin -
HY-17498R
Atenolol (Standard) -
HY-B0203A
Nebivolol hydrochlorideβ Receptor Blocker -
HY-B0528A
Octopamine hydrochlorideNeuromodulator -
HY-N2037A
Higenamine hydrochlorideLSD1 Inhibitor -
HY-12980
BatefenterolmAChR Antagonist -
HY-B1517A
Alprenolol hydrochloride5-HT Receptor Antagonist -
HY-B0528AR
Octopamine hydrochloride (Standard)Endogenous Metabolite -
HY-103210R
DSP-4 hydrochloride (Standard)Reference Standard
All Adrenergic Receptor Isoforms
More
Biological Activity
제품 설명
IC50 & Target
|
α adrenergic receptor |
In Vitro
Midodrine hydrochloride (30 μM, 0-24 h) increases p-AMPK and PPARδ expression in C2C12, HL1 and HepG2 cells[3].
Midodrine hydrochloride (30 μM, 0-1 min) increases Ca2+ in C2C12, HL1 and HepG2 cells[3].
Midodrine hydrochloride (30 μM) increases maximal mitochondrial oxidative phosphorylation and ATP content in C2C12 cells[3].
Midodrine hydrochloride (30-100 μM) reduces cellular lipid content in 3T3-L1 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:C2C12, HL1 and HepG2 cells
-
Concentration:30 μM
-
Incubation Time:0, 0.5, 1, 3, 6, and 24 h
-
Result:Increased p-AMPK and PPARδ expression.
In Vivo
Midodrine hydrochloride (5 mg/kg, i.g.) shows anti-hypotensive effects in orthostatic hypotension rats models[2].
Midodrine hydrochloride (0.3 mg/kg, p.o., 4 weeks.) relieves hypertension in spontaneously hypertensive rats models[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Orthostatic hypotension rats models[2]
-
Dosage:5 mg/kg
-
Administration:Orally gavage
-
Result:Remarkably increased the baselines of SBP, DBP and MAP, but decreased HR.
-
Animal Model:Spontaneously hypertensive rats models[3]
-
Dosage:0.3 mg/kg
-
Administration:Orally administration, 4 weeks
-
Result:Increased p-AMPK, PPARδ and PGC-1α expression.
Increased SDH activity and ATP levels.
Increased expression of uncoupling protein 3 (UCP3).
Decreased left ventricular mass and the harvested cardiac weight.
Reduced both systolic and diastolic BP after 1 week.
Reduced serum total cholesterol, LDL cholesterol, and HDL cholesterol.
Chemical Information
-
CAS No. 43218-56-0
-
Appearance Solid
-
분자량 290.74
-
화학식 C12H19ClN2O4
-
Color White to yellow
-
SMILES
O=C(NCC(C1=CC(OC)=CC=C1OC)O)CN.[H]Cl
-
Synonyms
(±)-Midodrine hydrochloride
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
In Vitro:
H2O : 100 mg/mL (343.95 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
-
Data Sheet (274 KB)
-
SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
-
Handling Instructions (2659 KB)
References
[1]. Criscuoli M, et al. Catecholamines released from the adrenal medulla exert a compensatory, protective effect at beta 2-adrenoceptors against Paf-induced death in mice. Br J Pharmacol. 1988 Jan;93(1):132-8. [Content Brief]
[2]. Inchan A, et al. Anti-hypotensive effect of "Yahom Navakot" in rats with orthostatic hypotension. J Tradit Complement Med. 2021 Aug 3;12(2):180-189. [Content Brief]
[3]. Lee YJ, et al. Stimulation of Alpha1-Adrenergic Receptor Ameliorates Cellular Functions of Multiorgans beyond Vasomotion through PPARδ. PPAR Res. 2020 Feb 1;2020:3785137. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.4395 mL | 17.1975 mL | 34.3950 mL | 85.9875 mL |
| 5 mM | 0.6879 mL | 3.4395 mL | 6.8790 mL | 17.1975 mL | |
| 10 mM | 0.3439 mL | 1.7197 mL | 3.4395 mL | 8.5987 mL | |
| 15 mM | 0.2293 mL | 1.1465 mL | 2.2930 mL | 5.7325 mL | |
| 20 mM | 0.1720 mL | 0.8599 mL | 1.7197 mL | 4.2994 mL | |
| 25 mM | 0.1376 mL | 0.6879 mL | 1.3758 mL | 3.4395 mL | |
| 30 mM | 0.1146 mL | 0.5732 mL | 1.1465 mL | 2.8662 mL | |
| 40 mM | 0.0860 mL | 0.4299 mL | 0.8599 mL | 2.1497 mL | |
| 50 mM | 0.0688 mL | 0.3439 mL | 0.6879 mL | 1.7197 mL | |
| 60 mM | 0.0573 mL | 0.2866 mL | 0.5732 mL | 1.4331 mL | |
| 80 mM | 0.0430 mL | 0.2150 mL | 0.4299 mL | 1.0748 mL | |
| 100 mM | 0.0344 mL | 0.1720 mL | 0.3439 mL | 0.8599 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Midodrine hydrochloride Related Classifications
HY-12749A Related Classifications
Powered by Bioz