A-424274
A-424274 is a positive allosteric modulator of the α4β2 neuronal nicotinic acetylcholine receptor with activity to enhance the efficacy of analgesics. A-424274 selectively enhances the potency of a range of nicotinic acetylcholine receptor agonists at the α4β2 receptor and, in preclinical models, co-administration with an α4β2 PAM significantly enhances the analgesic efficacy of ABT-594 at clinically well-tolerated doses in humans.
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- CAS No.: 1335145-56-6
- 화학식: C14H15N3
- 분자량:225.29
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
제품 설명
Chemical Information
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CAS No. 1335145-56-6
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분자량 225.29
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화학식 C14H15N3
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SMILES
[H][C@]12CN(C3=CC4=CC=CC=C4N=C3)C[C@@]1([H])NC2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
A-424274 Related Classifications
HY-116149 Related Classifications
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