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Cat. No.: HY-161021

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AC2 selective-IN-1

AC2 selective-IN-1 (compound 14) is a? potent (IC₅₀=4.45 μM), non-toxic, and selective mAC2 inhibitor.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₄₁H₄₇N₈O₈P
분자량:810.83

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

AC2 selective-IN-1 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

AC2 selective-IN-1 (compound 14) is a? potent (IC₅₀=4.45 μM), non-toxic, and selective mAC2 inhibitor^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	>10 μM Compound: 14	Cytotoxicity against human CCRF-CEM cells by CellTiter-Glo 2.0 assay Cytotoxicity against human CCRF-CEM cells by CellTiter-Glo 2.0 assay	[PMID: 37931521]
HeLa S3	IC₅₀	>10 μM Compound: 14	Cytotoxicity against human HeLa S3 cells by CellTiter-Glo 2.0 assay Cytotoxicity against human HeLa S3 cells by CellTiter-Glo 2.0 assay	[PMID: 37931521]
HepG2	IC₅₀	>10 μM Compound: 14	Cytotoxicity against human HepG2 cells by CellTiter-Glo 2.0 assay Cytotoxicity against human HepG2 cells by CellTiter-Glo 2.0 assay	[PMID: 37931521]
HL-60	IC₅₀	10 μM Compound: 14	Cytotoxicity against human HL-60 cells by CellTiter-Glo 2.0 assay Cytotoxicity against human HL-60 cells by CellTiter-Glo 2.0 assay	[PMID: 37931521]
NHDF	IC₅₀	>10 μM Compound: 14	Cytotoxicity against human NHDF cells by CellTiter-Glo 2.0 assay Cytotoxicity against human NHDF cells by CellTiter-Glo 2.0 assay	[PMID: 37931521]

Chemical Information

분자량 810.83
화학식 C₄₁H₄₇N₈O₈P
SMILES

NC1=C2C(N(CCOCP(N[C@H](C(OC(C)C)=O)CC3=CC=CC=C3)(N[C@@H](CC4=CC=CC=C4)C(OC(C)C)=O)=O)C=C2C5=CC=CC(C(N6)=NOC6=O)=C5)=NC=N1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pavel Kraina, et al. Discovery of a potent and selective human AC2 inhibitor based on 7-deazapurine analogues of adefovir. Bioorg Med Chem. 2023. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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