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Cat. No.: HY-129340

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AS-183

AS-183 is an inhibitor of cholesterol acyltransferase (ACAT) (IC₅₀=0.94 µM). AS-183 also inhibits the formation of cholesterol esters in HepG2, CaCo2 and THP-1 cells with IC₅₀ values of 18.1, 25.5 and 34.5 µM, respectively. AS-183 can be used in the study of atherosclerosis and hypercholesterolemia.

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CAS No.: 147317-12-2
화학식: C₁₉H₃₄O₃
분자량:310.47

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

AS-183 Chemical Structure

CAS No.: 147317-12-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biological Activity

제품 설명

All Acyltransferase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	IC₅₀	25.5 μM Compound: 101; AS-183	Reduction in cholesteryl ester synthesis in human Caco-2 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis Reduction in cholesteryl ester synthesis in human Caco-2 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis	[PMID: 36473091]
HepG2	IC₅₀	18.1 μM Compound: 101; AS-183	Reduction in cholesteryl ester synthesis in human HepG2 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis Reduction in cholesteryl ester synthesis in human HepG2 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis	[PMID: 36473091]
THP-1	IC₅₀	34.5 μM Compound: 101; AS-183	Reduction in cholesteryl ester synthesis in human THP-1 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis Reduction in cholesteryl ester synthesis in human THP-1 cells in presence of [1-14C]oleic acid incubated for 6 hrs by liquid scintillation counting analysis	[PMID: 36473091]

Chemical Information

CAS No. 147317-12-2
분자량 310.47
화학식 C₁₉H₃₄O₃
SMILES

O=C1C(O)(OC(C(CC(CC(CC(CC)C)C)C)C)=C1C)C
Structure Classification
- Others
Initial Source
- Microorganisms
Scedosporium sp.
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kuroda, et al. AS-183, a novel inhibitor of acyl-CoA: cholesterol acyltransferase produced by Scedosporium sp. SPC-15549. The Journal of Antibiotics 46.8 (1993): 1196-1202. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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AS-183

All Acyltransferase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AS-183 Related Classifications

HY-129340 Related Classifications