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Cat. No.: HY-159605

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Autophagy inducer 5

Autophagy inducer 5 (compound 21o) is a potent MCF-7 inhibitor (IC₅₀: 2 μM), and a potential breast cancer inhibitor. Autophagy inducer 5 induces cellular autophagy by activating the ROS/JNK signaling pathway, which increases ROS generation and JNK phosphorylation, exerting cytotoxic effects.

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화학식: C₄₁H₅₂N₄O₃
분자량:648.88

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Autophagy inducer 5 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All JNK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	7 μM Compound: 21o	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 39106494]
Bel-7402	IC₅₀	3.7 μM Compound: 21o	Antiproliferative activity against human Bel-7402 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human Bel-7402 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 39106494]
MCF-10A	IC₅₀	15.4 μM Compound: 21o	Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 39106494]
MCF7	IC₅₀	2 μM Compound: 21o	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 39106494]

Chemical Information

분자량 648.88
화학식 C₄₁H₅₂N₄O₃
SMILES

O=C([C@]1(C)CC[C@]2(C)CC[C@]3(C)[C@]4(C)C=CC5=C(C)C6=NC7=CC=C(C(NCCN(C)C)=O)C=C7N=C6C=C5C4=CC[C@@]3(C)[C@]2([H])C1)OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Scaffold Hopping of Pristimerin Provides Derivatives Containing a Privileged Quinoxaline Substructure as Potent Autophagy Inducers in Breast Cancer Cells

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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Autophagy inducer 5

All JNK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Autophagy inducer 5 Related Classifications

HY-159605 Related Classifications