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Cat. No.: HY-190158

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AZ-007

AZ-007 is a thiophene-2-carboximidamide fragment that binds to the 14-3-3σ/p53pT387 protein-protein interaction interface. AZ-007 is confirmed by X-ray crystallography to bind to the interfacial water network region between 14-3-3σ and the p53pT387 peptide, and it possesses interface selectivity. AZ-007 can be used in research related to the development of selective 14-3-3/p53 protein-protein interaction stabilizers.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2488429-19-0
화학식: C₁₄H₁₂N₄S
분자량:268.34

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

AZ-007 Chemical Structure

CAS No.: 2488429-19-0

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
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Biological Activity

제품 설명

In Vitro

AZ-007 binds to the 14-3-3σ/p53^pT387 interface in X-ray crystallography (PDB 6RWH) and produces no additional electron density in 14-3-3σ/TAZ^pS89 crystals, supporting selective targeting of the p53-bound interface over the TAZ-bound interface^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 2488429-19-0
분자량 268.34
화학식 C₁₄H₁₂N₄S
SMILES

N=C(N)C1=CC(C2=CC=CC=C2)=C(C3=CN=CN3)S1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Guillory X, et al. Fragment-based Differential Targeting of PPI Stabilizer Interfaces. Journal of medicinal chemistry. 2020 Jul 09;63(13):6694-6707.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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