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United States

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Cat. No.: HY-120544

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BAY-386

BAY-386, a chemical probe, is a PAR-1 antagonist that inhibits the expression of pro-inflammatory factors MCP-1 and CXCL1 in HUVEC.

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CAS No.: 1256941-06-6
화학식: C₂₂H₂₅F₃N₄O₅S
분자량:514.52

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

BAY-386 Chemical Structure

CAS No.: 1256941-06-6

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

BAY-386, a chemical probe, is a PAR-1 antagonist that inhibits the expression of pro-inflammatory factors MCP-1 and CXCL1 in HUVEC^[1].

IC₅₀ & Target

PAR-1, CXCL1^[1]

All Protease Activated Receptor (PAR) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Platelet	IC₅₀	>100 μM Compound: EUB0000291	Inhibition of platelet aggregation (human plasma, ADP, Collagen) Inhibition of platelet aggregation (human plasma, ADP, Collagen)	10.6019/CHEMBL4507269
Platelet	IC₅₀	0.14 μM Compound: EUB0000291	Inhibition of platelet aggregation (human plasma, thrombin) Inhibition of platelet aggregation (human plasma, thrombin)	10.6019/CHEMBL4507269
Platelet	IC₅₀	0.43 μM Compound: EUB0000291	Inhibition of platelet aggregation (human plasma, TRAP-6) (IC50) Inhibition of platelet aggregation (human plasma, TRAP-6) (IC50)	10.6019/CHEMBL4507269

Chemical Information

CAS No. 1256941-06-6
분자량 514.52
화학식 C₂₂H₂₅F₃N₄O₅S
SMILES

O=C(N1C[C@@H](C2=NC(C3CC3)=NO2)C[C@@H](C4=CC=C(OC(F)(F)F)C=C4)C1)N5CCS(CC5)(=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Santos S R F. Impact of PAR-1 upregulation upon EXT-1kd on balancing resistance and platelet activation[D]. Universidade de Lisboa (Portugal), 2022.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

BAY-386

All Protease Activated Receptor (PAR) Isoforms

Biological Activity

제품 설명

IC50 & Target

Cellular Effect

Chemical Information

순도&문서

References

Calculators

Help & FAQs

BAY-386 Related Classifications

HY-120544 Related Classifications

Bioz

Keywords

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