BGM1812
BGM1812 is a dual agonist of amylin (hAMY3R) (EC50 = 0.627 nM) and CGRP Receptor (hCTR) (EC50 = 2.27 nM). BGM1812 achieves weight loss, increases the proportion of lean body mass, and reduces fat mass in diet-induced obese (DIO) rats. BGM1812 is applicable to research related to obesity.
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- 화학식: C182H299N49O61
- 분자량:4149.61
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
BGM1812 (4-fold serial dilutions from 200 μM stock; 1 h) potently activates hAMY3R (EC50 = 0.627 nM) and hCTR (EC50 = 2.270 nM) in HEK-293 cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | T1/2 | Tmax | Cmax | AUC0-t | AUC0-∞ |
|---|---|---|---|---|---|---|---|
| Rat[1] | 1 mg/kg | s.c. | 21.1 h | 24 h | 5303 ng/mL | 264931 ng·h/mL | 282265 |
BGM1812 (0.012-0.12 mg/kg; subcutaneous injection; once every 3 days; total 10 doses) achieves body weight reduction, dose-dependent weight loss, and favorable body composition changes (increased proportion of lean body mass, decreased fat mass) in diet-induced obesity (DIO) rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 6-8 weeks old, 210-240 g)[1]
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Dosage:1 mg/kg
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Administration:s.c.; single dose
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Result:Had a sustained inhibitory effect on food intake, significantly reducing food intake 3-4 days after administration.
Reduced body weight, demonstrating a sustained weight loss advantage.
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Animal Model:Sprague-Dawley (male, 20 weeks old, diet-induced obesity model)[1]
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Dosage:0.012 mg/kg; 0.04 mg/kg; 0.12 mg/kg
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Administration:s.c.; every third day; 10 doses
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Result:Reduced weight and food intake, increased lean body mass, and reduced fat mass.
Chemical Information
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분자량 4149.61
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화학식 C182H299N49O61
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Sequence
{γGlu-C20 diacid}-Arg-Asp-Gly-Thr-Ala-Thr-Lys-Ala-Thr-Glu-Arg-{αMeLeu}-Ala-{Aad}-Phe-Leu-Gln-Arg-Ser-Ser-Phe-{Sar}-Ala-{Sar}-Leu-Ser-Ser-Thr-Glu-Thr-Gly-Ser-Asn-Thr-{Hyp}-NH2 (Lactm bridge:Asp3-Lys8)
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Sequence Shortening
{γGlu-C20 diacid}-RDGTATKATER-{αMeLeu}-A-{Aad}-FLQRSSF-{Sar}-A-{Sar}-LSSTETGSNT-{Hyp}-NH2 (Lactm bridge:Asp3-Lys8)
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BGM1812 Related Classifications
HY-P11587 Related Classifications
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