Gangaleoidin
Gangaleoidin is a FOXM1 inhibitor with an IC50 of 2.8 μM. Gangaleoidin inhibits interaction between FOXM1’s DNA-binding domain and target DNA sequence, downregulates FOXM1 and downstream target gene CCNB1 at the transcriptional level. Gangaleoidin suppresses proliferation of FOXM1-overexpressing breast cancer cells. Gangaleoidin can be used for the research of breast cancer.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 55365-63-4
- 화학식: C18H14Cl2O7
- 분자량:413.21
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
All DNA/RNA Synthesis Isoforms
More
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO | Inhibition |
15.0060 %
Compound: GANGALEOIDIN
|
Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
|
[PMID: 23571415] |
| CHO | Inhibition |
4.09271 %
Compound: GANGALEOIDIN
|
Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
|
[PMID: 23571415] |
Gangaleoidin (30 μM; 24-72 h) inhibits proliferation of FOXM1-overexpressing MDA-MB-231 and MCF-7 breast cancer cell MDA-MB-231 and MCF-7[1].
Gangaleoidin (30 μM; 24 h) downregulates mRNA expression of FOXM1c and CCNB1, but not CDC25b, in MDA-MB-231 breast cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MDA-MB-231 and MCF-7 cells
-
Concentration:30 μM
-
Incubation Time:24, 36, 72 h
-
Result:Significantly reduced relative cell viability in both MDA-MB-231 and MCF-7 cells.
-
Cell Line:FOXM1-overexpressing MDA-MB-231 breast cancer cell line
-
Concentration:30 μM
-
Incubation Time:24 h
-
Result:Significantly reduced mRNA expression of FOXM1c (autoregulated FOXM1 isoform) and the FOXM1 downstream target gene CCNB1.
Did not significantly affect expression of CDC25b.
Chemical Information
-
CAS No. 55365-63-4
-
분자량 413.21
-
화학식 C18H14Cl2O7
-
SMILES
O=C1OC2=C(OC3=C(C(O)=C(C(C)=C13)Cl)Cl)C(C)=C(C(OC)=O)C(OC)=C2
-
Structure Classification
-
Initial Source
Lecanora chlarotera
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Lee MY, et al. Development of a FOXM1-DBD Binding Assay for High-Throughput Screening Using TR-FRET Assay. Biol Pharm Bull. 2021;44(10):1484-1491. [Content Brief]
[2]. Tuovinen V, et al. Tremella macrobasidiata and Tremella variae have abundant and widespread yeast stages in Lecanora lichens. Environ Microbiol. 2021 May;23(5):2484-2498. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Gangaleoidin Related Classifications
HY-N19821 Related Classifications
Powered by Bioz