Slc6a9 - solute carrier family 6 member 9 Gene

Also Known as Glyt1; GLYT-1; GLYT-1b

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116509

About Slc6a9

Primary_assembly 5: 131,374,542-131,408,728 forward strand.mRatBN7.2:CM026978.1

This gene has 2 transcripts (splice variants), 206 orthologues, 20 paralogues and is associated with 7 phenotypes. Biased expression in Brain (RPKM 173.1), Liver (RPKM 15.1) and 8 other tissues.

Summary

Enables glycine transmembrane transporter activity. Involved in glycine import across plasma membrane. Located in dense core granule; endosome; and plasma membrane. Is active in hippocampal mossy fiber to CA3 synapse; parallel fiber to Purkinje cell synapse; and postsynaptic density. Is integral component of postsynaptic membrane; integral component of presynaptic membrane; and integral component of synaptic vesicle membrane. Orthologous to human SLC6A9 (solute carrier family 6 member 9). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a9 Products (1)

mRNA Protein Name
NM_053818.3 NP_446270.1 sodium- and chloride-dependent glycine transporter 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glycine transmembrane transporter activity IDA
IDA: Inferred from direct assay
12091465 RGD
enables glycine:sodium symporter activity IDA
IDA: Inferred from direct assay
1534013 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16181645 RGD
Biological Process GO Annotation Evidence References Source
involved in glycine import across plasma membrane IDA
IDA: Inferred from direct assay
12091465 RGD
Cellular Component GO Annotation Evidence References Source
is active in asymmetric synapse IDA
IDA: Inferred from direct assay
15749988 RGD
located in dense core granule IDA
IDA: Inferred from direct assay
12091465 RGD
located in endosome IDA
IDA: Inferred from direct assay
12091465 RGD
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
15749988 RGD
is active in parallel fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
15749988 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
12091465 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
15749988 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
15749988 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
15749988 RGD
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
24036061 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc6a9 Protein Structure

SLC6sbd_GlyT1

SLC6sbd_GlyT1: cd11498 (15 - 598)

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  • 638 a.a.
Protein Preferred Names Protein Names

sodium- and chloride-dependent glycine transporter 1

  • glycine transporter 1

  • solute carrier family 6 (neurotransmitter transporter, glycine), member 9

Slc6a9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Slc6a9 P28572 Dlg4 Rattus norvegicus P31016
Far-WB
16271045
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS13320 SLC6A9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13321 Slc6a9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13322 Slc6a9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc6a9 NCBI NCBI:6536