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Erbb3 - erb-b2 receptor tyrosine kinase 3 Gene

Also Known as Her3; Erbb-3; Erbb3r

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13867

About Erbb3

Chromosome 10: 128,403,392-128,425,521 reverse strand.GRCm39:CM001003.3

This gene has 1 transcript (splice variant), 280 orthologues, 53 paralogues and is associated with 81 phenotypes. Biased expression in colon adult (RPKM 49.8), large intestine adult (RPKM 38.8) and 13 other tissues.

Summary

Predicted to enable several functions, including ErbB-3 class receptor binding activity; neuregulin binding activity; and transmembrane signaling receptor activity. Acts upstream of or within several processes, including nervous system development; positive regulation of calcineurin-NFAT signaling cascade; and positive regulation of cardiac muscle tissue development. Located in apical plasma membrane and lateral plasma membrane. Is expressed in several structures, including alimentary system; heart; nervous system; reproductive system; and sensory organ epithelium. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Erbb3 Products (1)

mRNA	Protein	Name
NM_010153.2	NP_034283.1	receptor tyrosine-protein kinase erbB-3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables neuregulin receptor activity	IMP IMP: Inferred from mutant phenotype	18760695	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11276227	MGI
enables signaling receptor activity	IDA IDA: Inferred from direct assay	8702723	MGI
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	9742126	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in ERBB2-ERBB3 signaling pathway	IDA IDA: Inferred from direct assay	8702723	MGI
involved in ERBB2-ERBB3 signaling pathway	IMP IMP: Inferred from mutant phenotype	18760695	MGI
involved in Schwann cell development	IMP IMP: Inferred from mutant phenotype	10704452	MGI
acts upstream of or within Schwann cell differentiation	IMP IMP: Inferred from mutant phenotype	9338783	MGI
acts upstream of or within cranial nerve development	IMP IMP: Inferred from mutant phenotype	9338783	MGI
acts upstream of or within endocardial cushion development	IMP IMP: Inferred from mutant phenotype	9362461	MGI
acts upstream of motor neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	9338783	MGI
involved in myelination	IMP IMP: Inferred from mutant phenotype	10704452	MGI
acts upstream of or within negative regulation of motor neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	9338783	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	9338783	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	9338783	MGI
acts upstream of or within peripheral nervous system development	IMP IMP: Inferred from mutant phenotype	9362461	MGI
acts upstream of or within positive regulation of calcineurin-NFAT signaling cascade	IGI IGI: Inferred from genetic interaction	19179536	MGI
acts upstream of or within positive regulation of cardiac muscle tissue development	IMP IMP: Inferred from mutant phenotype	24364879	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24364879	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15306553	MGI
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	15306553	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	8702723	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Erbb3 Protein Structure

Recep_L_domain

Furin-like

Recep_L_domain

GF_recep_IV

TM_ErbB3

PKc_like

0
300
600
900
1200
1339 a.a.

Protein Preferred Names	Protein Names
receptor tyrosine-protein kinase erbB-3	avian erythroblastosis oncogene B 3 receptor c-erbB-3 glial growth factor receptor proto-oncogene-like protein c-ErbB-3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3

Erbb3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Erbb3	Q61526	Erbb2	Mus musculus	P70424	Anti Bait CoIP	20639901

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Erbb3 Proteins

Cat. No.	상품명	Accession	Purity
HY-P70857	HER3 Protein, Mouse (HEK293, His)	Q61526 (S20-H641)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	상품명	Purity	Rare Diseases
HY-B0426A	Olopatadine hydrochloride	99.83%	Unkown
HY-W062109	Olopatadine	98.94%	Unkown
HY-B0426AR	Olopatadine hydrochloride (Standard)	/	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	상품명	효과	Purity	Phase
HY-118998	TX2-121-1	Inhibitor	/	Phase 3
HY-13050	Sapitinib	Inhibitor	99.93%	Phase 2

Inhibitory Antibodies (6)

Cat. No.	상품명	효과	Purity	Phase
HY-P99275	Patritumab	Inhibitor	99.28%	Phase 3
HY-P99672	Istiratumab	Inhibitor	98.45%	Phase 2
HY-P991240	CDX-3379	Inhibitor	99.38%	Phase 2
HY-P991524	MM-111	Inhibitor	/	Phase 2
HY-P99304	Lumretuzumab	Inhibitor	≥99.0%	Phase 1
HY-P991244	REGN-1400	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-100848	TX1-85-1	Inhibitor	99.65%	Unkown
HY-168438	ERBB agonist-1		99.16%	Unkown
HY-18609	PD158780	Inhibitor	99.47%	Unkown
HY-E70715	ERBB2 775YVMA776 Recombinant Human Active Protein Kinase		/	Unkown
HY-13050A	Sapitinib fumarate	Inhibitor	/	Unkown
HY-B0426AS2	Olopatadine-d6 hydrochloride		/	Unkown
HY-RS04469	ERBB3 Human Pre-designed siRNA Set A		/	Unkown
HY-RS04470	Erbb3 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS04471	Erbb3 Rat Pre-designed siRNA Set A		/	Unkown
HY-W062109S	Olopatadine-d6		/	Unkown
HY-B0426AS	Olopatadine-d3 hydrochloride		/	Unkown

Inhibitory Antibodies (6)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-P991159	Ruzaltatug	Inhibitor	95.69%	Unkown
HY-P992128	Rinumafusp alfa	Inhibitor	97.09%	Unkown
HY-P991241	Anti-ERBB3/HER3 (29Z6)	Inhibitor	/	Unkown
HY-P991243	MP-RM-1	Inhibitor	96.29%	Unkown
HY-P991245	Anti-ERBB3/HER3 (SGP1)	Inhibitor	/	Unkown
HY-P991983	DB-1310 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Erbb3	NCBI	NCBI:2065