DBNL - drebrin like Gene

Also Known as ABP1; HIP55; SH3P7; HIP-55

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 28988

About DBNL

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:44,044,702-44,069,456 (from NCBI)

This gene has 22 transcripts (splice variants), 268 orthologues and 4 paralogues. Ubiquitous expression in esophagus (RPKM 54.1), spleen (RPKM 52.7) and 25 other tissues.

Summary

Enables Cadherin binding activity. Predicted to be involved in several processes, including Rac protein signal transduction; nervous system development; and podosome assembly. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DBNL Products (6)

mRNA	Protein	Name
NM_001014436.3	NP_001014436.1	drebrin-like protein isoform b
NM_001122956.2	NP_001116428.1	drebrin-like protein isoform c
NM_001284313.2	NP_001271242.1	drebrin-like protein isoform d
NM_001284315.2	NP_001271244.1	drebrin-like protein isoform e
NM_001362723.2	NP_001349652.1	drebrin-like protein isoform f
NM_014063.7	NP_054782.2	drebrin-like protein isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	25468996	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DBNL Protein Structure

Cofilin_ADF

SH3_9

0
100
200
300
400
430 a.a.

Protein Preferred Names	Protein Names
drebrin-like protein	HPK1-interacting protein of 55 kDa

DBNL Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DBNL	Q9UJU6	SH2D4A	Homo sapiens	Q9H788-2	Y2H Prey Pooling	25416956
Intra	DBNL	Q9UJU6	SH2D4A	Homo sapiens	Q9H788-2	Validated Y2H	25416956
Intra	DBNL	Q9UJU6	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	DBNL	Q9UJU6	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	DBNL	Q9UJU6	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	DBNL	Q9UJU6	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	DBNL	Q9UJU6	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	DBNL	Q9UJU6	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	DBNL	Q9UJU6	ACD	Homo sapiens	Q96AP0	Pull Down	21044950
Intra	DBNL	Q9UJU6	ACD	Homo sapiens	Q96AP0	BiFC	21044950
Intra	DBNL	Q9UJU6	SH3BP2	Homo sapiens	P78314	Pull Down	17306257
Intra	DBNL	Q9UJU6	SH3BP2	Homo sapiens	P78314	IF	17306257
Intra	DBNL	Q9UJU6	SH2D4A	Homo sapiens	Q9H788	Validated Y2H	25416956
Intra	DBNL	Q9UJU6	SH2D4A	Homo sapiens	Q9H788	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Glycogen Storage Disease X	Myopathy Due To Phosphoglycerate Mutase Deficiency GSD10 Pgamm Deficiency Gsd X Muscle Phosphoglycerate Mutase Deficiency Glycogen Storage Disease Type X Phosphoglycerate Mutase Deficiency Gsdx Pgam Deficiency Phosphoglycerate Mutase, Muscle, Deficiency Of Deficiency Mutase Phosphoglycerate Glycogen Storage Disease Due To Phosphoglycerate Mutase Deficiency Gsd Due To Phosphoglycerate Mutase Deficiency Gsd Type 10 Glycogenosis Due To Phosphoglycerate Mutase Deficiency Glycogen Storage Disease 10 Storage Disease, Glycogen, Type X

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS03551	DBNL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DBNL	VGNC	VGNC:97186
Mus musculus	DBNL	MGD	MGI:700006
Felis catus	DBNL	VGNC	VGNC:61349
Macaca mulatta	DBNL	VGNC	VGNC:108394
Bos taurus	DBNL	VGNC	VGNC:27893
Rattus norvegicus	DBNL	RGD	RGD:70941
Others	DBNL	NCBI