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NKX6-1 - NK6 homeobox 1 Gene

Also Known as NKX6A; NKX6.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4825

About NKX6-1

Cytogenetic location: 4q21.23 Genomic coordinates (GRCh38): 4:84,491,985-84,499,292 (from NCBI)

This gene has 2 transcripts (splice variants), 202 orthologues and 13 paralogues. Biased expression in esophagus (RPKM 3.3), thyroid (RPKM 0.9) and 4 other tissues.

Summary

In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM, Mar 2008]

NKX6-1 Products (1)

mRNA	Protein	Name
NM_006168.3	NP_006159.2	homeobox protein Nkx-6.1

NKX6-1 Protein Structure

Homeobox

0
100
200
300
367 a.a.

Protein Preferred Names	Protein Names
homeobox protein Nkx-6.1	NK homeo box, family 6, member A

NKX6-1 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P81474	NKX6.1 Antibody (YA1219)	IHC-P	Human
HY-P81474A	NKX6.1 Antibody (YA1219)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Pancreatic Agenesis	Partial Pancreatic Agenesis Congenital Pancreatic Agenesis Partial Agenesis Of The Pancreas Agenesis, Pancreatic Pancreatic Agenesis, Congenital
Maturity-Onset Diabetes Of The Young, Type 4	Maturity-Onset Diabetes Of The Young Type 4 MODY4 Mody, Type Iv Mody Type 4 Mody, Type 4 Maturity-Onset Diabetes Of The Young 4 Mody-4 Diabetes Of The Young, Maturity-Onset, Type 4 Maturity-Onset Diabetes Of The Young, Type Iv
Neonatal Diabetes	Neonatal Diabetes Mellitus Diabetes Mellitus Syndrome In Newborn Infant Ndm
Maturity-Onset Diabetes Of The Young, Type 3	Maturity-Onset Diabetes Of The Young Type 3 MODY3 Mody, Type Iii Mody Type 3 Mody, Type 3 Maturity-Onset Diabetes Of The Young 3 Mody-3 Diabetes Of The Young, Maturity-Onset, Type 3
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset
Permanent Neonatal Diabetes Mellitus	Pndm Permanent Diabetes Mellitus Of Infancy Pdmi Neonatal Diabetes Mellitus, Permanent
Maturity-Onset Diabetes Of The Young, Type 1	Maturity-Onset Diabetes Of The Young Type 1 MODY1 Mild Juvenile Diabetes Mellitus Mody, Type I Diabetes Mellitus Type 2 Mody Type 1 Mody, Type 1 Maturity-Onset Diabetes Of The Young 1 Mody-1 Diabetes Of The Young, Maturity-Onset, Type 1
Pancreatic Cystadenoma	Cystadenoma Of Pancreas
Diabetes Mellitus	Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS09335	NKX6-1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NKX6-1	VGNC	VGNC:78535
Rattus norvegicus	NKX6-1	RGD	RGD:69318
Bos taurus	NKX6-1	VGNC	VGNC:32107
Canis familiaris	NKX6-1	VGNC	VGNC:54334
Macaca mulatta	NKX6-1	VGNC	VGNC:75356
Mus musculus	NKX6-1	MGD	MGI:1206039
Others	NKX6-1	NCBI