Fzr1 - fizzy and cell division cycle 20 related 1 Gene

Also Known as FZR; Fyr; Cdh1; FZR2; HCDH; HCDH1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56371

Summary

Predicted to enable anaphase-promoting complex binding activity and ubiquitin Ligase activator activity. Involved in negative regulation of cell aging and positive regulation of cell population proliferation. Acts upstream of or within lens fiber cell differentiation; proteolysis involved in cellular protein catabolic process; and regulation of meiotic nuclear division. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be part of anaphase-promoting complex. Is expressed in several structures, including central nervous system; liver; oocyte; sensory organ; and skeleton. Orthologous to human FZR1 (fizzy and cell division cycle 20 related 1). [provided by Alliance of Genome Resources, Apr 2022]

Fzr1 Products (1)

mRNA Protein Name
NM_019757.1 NP_062731.1 fizzy-related protein homolog

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17215516 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within lens fiber cell differentiation IMP
IMP: Inferred from mutant phenotype
17215516 MGI
involved in negative regulation of cellular senescence IMP
IMP: Inferred from mutant phenotype
21241890 MGI
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
21241890 MGI
acts upstream of or within proteolysis involved in protein catabolic process IMP
IMP: Inferred from mutant phenotype
23541922 MGI
acts upstream of or within regulation of meiotic nuclear division IDA
IDA: Inferred from direct assay
17190794 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fizzy-related protein homolog

  • cdh1/Hct1 homolog

  • cell division cycle 20 related 1

  • fizzy/cell division cycle 20 related 1

Fzr1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Fzr1 Q9R1K5 Sirt2 Mus musculus Q8VDQ8
Anti Bait CoIP
22014574
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS05186 FZR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22176 Fzr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28698 Fzr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fzr1 NCBI NCBI:51343