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Cat. No.: HY-136734

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JAK2-IN-5

JAK2-IN-5 (Compound 13) is a selective JAK kinase inhibitor, with an IC₅₀ of 0.078 μM against JAK-2 and an IC₅₀ of 0.206 μM against JAK-2^V617F. JAK2-IN-5 can be used for the research of myeloproliferative disorders.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1110502-30-1
화학식: C₁₇H₂₀N₄O₂S
분자량:344.43

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

JAK2-IN-5 Chemical Structure

CAS No.: 1110502-30-1

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-13034
Gandotinib

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

JAK2

0.078 μM (IC₅₀)

JAK2^V617F

0.206 μM (IC₅₀)

All JAK Isoforms :

In Vitro

JAK2-IN-5 potently inhibits JAK-2 WT kinase with an IC₅₀ of 78 nM and a ligand efficiency of 0.41 kcal mol^-1^[1].
JAK2-IN-5 inhibits JAK-2^V617F mutant kinase with an IC₅₀ of 206 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1110502-30-1
분자량 344.43
화학식 C₁₇H₂₀N₄O₂S
SMILES

O=S(=O)(NC(C)(C)C)C=1C=CC(=CC1)C2=CC=C3NN=C(N)C3=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Antonysamy S, et al. Fragment-based discovery of JAK-2 inhibitors. Bioorg Med Chem Lett. 2009;19(1):279-282. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
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JAK2-IN-5

All JAK Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

JAK2-IN-5 Related Classifications

HY-136734 Related Classifications

Bioz

Keywords

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