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Cat. No.: HY-159627

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Met-AMS

Met-AMS (Compound 50) is a sulfonamide analog of methionyl-adenylate (Met-AMP) and an inhibitor of isoleucyl-tRNA synthetase (IleRS) with an IC₅₀ of 7 nM.

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CAS No.: 560071-70-7
화학식: C₁₅H₂₃N₇O₇S₂
분자량:477.52

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Met-AMS Chemical Structure

CAS No.: 560071-70-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Met-AMS (Compound 50) is a sulfonamide analog of methionyl-adenylate (Met-AMP) and an inhibitor of isoleucyl-tRNA synthetase (IleRS) with an IC₅₀ of 7 nM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
PBMC	IC₅₀	0.5 μM Compound: MetSA	Immunosuppressive activity against human PBMC assessed as inhibition of allogenic mixed lymphocyte reaction Immunosuppressive activity against human PBMC assessed as inhibition of allogenic mixed lymphocyte reaction	[PMID: 18438987]

Chemical Information

CAS No. 560071-70-7
분자량 477.52
화학식 C₁₅H₂₃N₇O₇S₂
SMILES

O[C@H]1[C@@H](O)[C@H](N2C=NC3=C(N)N=CN=C32)O[C@@H]1COS(=O)(NC([C@H](CCSC)N)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Lee J, et al. N-Alkoxysulfamide, N-hydroxysulfamide, and sulfamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases. Bioorg Med Chem Lett. 2003;13(6):1087-1092. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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