Csk
The Csk (C-terminal Src kinase) family is a small family of non-receptor tyrosine kinases, with CSK and MATK (also called CHK) in humans. Both carry a compact SH3-SH2-kinase architecture but, unlike Src-family enzymes, lack an N-terminal fatty-acylation signal and a C-terminal regulatory tyrosine. Their essential function is to phosphorylate the conserved C-terminal tyrosine of Src-family kinases, such as Src tyrosine 527, creating an intramolecular SH2-bound autoinhibited conformation. Through this negative feedback, Csk-family enzymes restrain Src signaling in platelets, immune cells and epithelia. CSK is ubiquitous and essential for development, whereas MATK is largely confined to hematopoietic and neural lineages and can additionally inhibit Src through direct SH2 binding.
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Csk Recombinant Proteins (3)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 화학식: Human
- 분자량: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
