(RS)-AMPA hydrobromide
Based on 1 Customer Validation
(RS)-AMPA hydrobromide ((±)-AMPA hydrobromide) is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA hydrobromide does not interfere with binding sites for kainic acid or NMDA receptors.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 99.50%
- CAS No.: 171259-81-7
- 화학식: C7H11BrN2O4
- 분자량:267.08
-
보관:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
용액&용해도
- 순도&문서
- References
-
Help & FAQs
-
HY-101165
CyclothiazideAMPA Receptors PAM -
HY-100815A
(S)-AMPAAMPA Receptor Agonist -
HY-15066A
CNQX disodiumiGluR Antagonist -
HY-103230
IEM-1460 -
HY-15068
NBQXAMPA Receptor Antagonist -
HY-18663
CP-465022AMPA Receptor Antagonist -
HY-101528
IDRA 21AMPA Modulator -
HY-15071
YM90KAMPA Receptor Antagonist -
HY-12597
Quisqualic acidmGluR Activator -
HY-15068A
NBQX disodiumAMPA Receptor Antagonist -
HY-12505
CX546Autophagy Inducer -
HY-10933
CX516AMPA Receptor PAM
All iGluR Isoforms
More
Biological Activity
제품 설명
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
>10 μM
Compound: GNF-Pf-2579
|
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
|
[PMID: 18579783] |
In Vitro
(RS)-AMPA hydrobromide induces dose-dependent depolarization in cultured fetal rat brainstem and lumbosacral spinal cord neurons by activating glutamate/quisqualate-preferring receptors[1].
(RS)-AMPA hydrobromide activates recombinant GluR-A/GluR-B AMPA receptors in cultured mammalian cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 171259-81-7
-
Appearance Solid
-
분자량 267.08
-
화학식 C7H11BrN2O4
-
Color White to off-white
-
SMILES
O=C1C(CC(N)C(O)=O)=C(C)ON1.Br
-
Synonyms
(±)-AMPA hydrobromide
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
In Vitro:
DMSO : 50 mg/mL (187.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 5 mg/mL (18.72 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
-
Data Sheet (275 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
[1]. Hösli L, et al. Effects of the glutamate analogue AMPA and its interaction with antagonists on cultured rat spinal and brain stem neurones. Neurosci Lett. 1983 Mar 28;36(1):59-62. [Content Brief]
[2]. Sommer B, et al. Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science. 1990 Sep 28;249(4976):1580-5. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.7442 mL | 18.7210 mL | 37.4420 mL | 93.6049 mL |
| 5 mM | 0.7488 mL | 3.7442 mL | 7.4884 mL | 18.7210 mL | |
| 10 mM | 0.3744 mL | 1.8721 mL | 3.7442 mL | 9.3605 mL | |
| 15 mM | 0.2496 mL | 1.2481 mL | 2.4961 mL | 6.2403 mL | |
| DMSO | 20 mM | 0.1872 mL | 0.9360 mL | 1.8721 mL | 4.6802 mL |
| 25 mM | 0.1498 mL | 0.7488 mL | 1.4977 mL | 3.7442 mL | |
| 30 mM | 0.1248 mL | 0.6240 mL | 1.2481 mL | 3.1202 mL | |
| 40 mM | 0.0936 mL | 0.4680 mL | 0.9360 mL | 2.3401 mL | |
| 50 mM | 0.0749 mL | 0.3744 mL | 0.7488 mL | 1.8721 mL | |
| 60 mM | 0.0624 mL | 0.3120 mL | 0.6240 mL | 1.5601 mL | |
| 80 mM | 0.0468 mL | 0.2340 mL | 0.4680 mL | 1.1701 mL | |
| 100 mM | 0.0374 mL | 0.1872 mL | 0.3744 mL | 0.9360 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
(RS)-AMPA hydrobromide Related Classifications
HY-100815C Related Classifications
Powered by Bioz