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![[D-p-Cl-Phe6,Leu17]-VIP](https://file.medchemexpress.com/product_pic/hy-p1159.gif "Click to View [D-p-Cl-Phe6,Leu17]-VIP Product Detail")
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
67 Results for "
VIP
" in MedChemExpress (MCE) Product Catalog:
Products (67)
67 Results for "VIP" in MCE Product Catalog:
5
5 Cited Publications
Cat. No.: HY-P0221
CAS No.: 137061-48-4
Synonyms: Pituitary Adenylate Cyclase Activating Polypeptide 38
2
2 Cited Publications
Cat. No.: HY-P0012
CAS No.: 40077-57-4
Synonyms: Vasoactive Intestinal Peptide (human, rat, mouse, rabbit, canine, porcine)
Target:
2
2 Cited Publications
Synonyms: (+)-BAY-1251152; (+)-VIP152; (S)-Enitociclib
Target:
Enitociclib ((+)-BAY-1251152; (+)-VIP152) is a selective CDK9 inhibitor (IC50=3 nM) that inhibits transcriptional elongation by blocking Ser2/Ser5 phosphorylation of RNA polymerase II. Enitociclib specifically depletes key short-lived proteins such as c-MYC, MCL-1 and induces tumor cell apoptosis. Enitociclib also interferes with the production of enhancer RNAs (eRNA) and enhancer-promoter interactions, and downregulates oncogene expression at the epigenetic level. Enitociclib exerts synergistic effects with agents including Bortezomib (HY-10227), Lenalidomide (HY-A0003), Pomalidomide (HY-10984), Venetoclax (HY-15531) and Paclitaxel (HY-B0015), and even reverses paclitaxel resistance. Enitociclib serves as a vital research tool for various malignancies such as double-hit diffuse large B-cell lymphoma, multiple myeloma and pancreatic ductal adenocarcinoma .
2
2 Cited Publications
Cat. No.: HY-P0220A
Target:
연구분야:
2
2 Cited Publications
Cat. No.: HY-P0220
CAS No.: 143748-18-9
Target:
연구분야:
2
2 Cited Publications
Synonyms: (R)-Enitociclib; (-)-BAY-1251152; (-)-VIP152
Target:
연구분야:
(-)-Enitociclib ((R)-Enitociclib) is an enantiomer of Enitociclib (HY-103019E) with an optical rotation of (-). Enitociclib is a selective CDK9 inhibitor and apoptosis inducer. Enitociclib inhibits CDK9 activity and reduces the phosphorylation of Ser2 in the carboxyl-terminal domain (CTD) of RNA polymerase Pol II, thereby downregulating the transcription of key oncogenes such as MYC and MCL1. Enitociclib has anti-proliferative activity targeting MYC + lymphoma and multiple myeloma (MM) cells, and has synergistic effects with Bortezomib (HY-10227) and Lenalidomide (HY-A0003), and can be used in the research of hematological malignancies .
2
2 Cited Publications
Cat. No.: HY-P0012A
CAS No.: 1444827-29-5
Synonyms: Vasoactive Intestinal Peptide acetate salt (human, rat, mouse, rabbit, canine, porcine)
Target:
1
1 Cited Publications
Cat. No.: HY-P1023
CAS No.: 69698-54-0
Target:
연구분야:
1
1 Cited Publications
Cat. No.: HY-P1159A
Target:
1
Synonyms: (±)-BAY-1251152; (±)-VIP152
Target:
연구분야:
(±)-Enitociclib ((±)-BAY-1251152) is the racemic mixture of Enitociclib (HY-103019E). Enitociclib is a selective CDK9 inhibitor and apoptosis inducer. Enitociclib inhibits CDK9 activity and reduces the phosphorylation of Ser2 in the carboxyl-terminal domain (CTD) of RNA polymerase Pol II, thereby downregulating the transcription of key oncogenes such as MYC and MCL1. Enitociclib has anti-proliferative activity targeting MYC + lymphoma and multiple myeloma (MM) cells, and has synergistic effects with Bortezomib (HY-10227) and Lenalidomide (HY-A0003), and can be used in the research of hematological malignancies .
Cat. No.: HY-P0221C
CAS No.: 129405-61-4
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연구분야:
Cat. No.: HY-P5005
CAS No.: 125093-93-8
Target:
Cat. No.: HY-P11288
CAS No.: 2871680-36-1
Target:
연구분야:
Cat. No.: HY-P11288A
Target:
연구분야:
Cat. No.: HY-P4195A
Target:
연구분야:
Cat. No.: HY-P10948A
Target:
연구분야:
Cat. No.: HY-P4776
CAS No.: 202463-00-1
Target:
연구분야:
Cat. No.: HY-P1159
CAS No.: 102805-45-8
Target:
Cat. No.: HY-P4127A
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
