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Cat. No.: HY-151342

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Ser@TPP@CUR

Ser@TPP@CUR is a Curcumin (HY-N0005) derivative. Ser@TPP@CUR effectively ameliorates injured renal tubular epithelial cells and improves renal functions of acute kidney injury (AKI) mice. Ser@TPP@CUR can be used for the research of AKI .

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CAS No.: 3032193-12-4
화학식: C₄₇H₄₇BrNO₉P
분자량:880.76

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Ser@TPP@CUR Chemical Structure

CAS No.: 3032193-12-4

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

Ser@TPP@CUR (7.16 μg/mL; 24 h) effectively reduces ROS level in inflammatory HK-2 cells^[1].
Ser@TPP@CUR (3 μg/mL; 24 h) effects cell viability and inhibits expression levels of cytosolic cytochrome c, cleaved caspase-3, and cleaved caspase-9 of LPS-induced HK-2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

LPS-induced HK-2 cell lines
Concentration:

3 μg/mL
Incubation Time:

24 hours
Result:

Significantly improved cell viability of LPS-induced HK-2 cells.

In Vivo

Ser@TPP@CUR (4 mg/kg; i.v. once) shows a better distribution in renal tissues via KIM-1-receptor-mediated endocytosis in renal tubule epithelial cells and restores renal function of AKI mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

AKI mice^[1]
Dosage:

4 mg/kg
Administration:

Intravenous injection; 4 mg/kg once
Result:

Showed a better distributionin in renal tissues than CUR at 2 hours after injection and restored renal function of AKI mice by alleviated Scr and BUN levels.

Chemical Information

CAS No. 3032193-12-4
분자량 880.76
화학식 C₄₇H₄₇BrNO₉P
SMILES

COC(C=C1/C=C/C(CC(/C=C/C2=CC(OC)=C(OC(CCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O)C=C2)=O)=O)=C(C=C1)OC([C@@H](N)CO)=O.[Br-]
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yan X, et al. A Stepwise Targeting Curcumin Derivative, Ser@TPP@CUR, for Acute Kidney Injury. ACS Med Chem Lett. 2022 Mar 8;13(4):554-559. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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