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Cat. No.: HY-187835

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WO677

WO677 is a KCNT1 inhibitor that can be used in studies of nervous system disorders associated with KCNT1 function, such as epilepsy.

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CAS No.: 3088105-77-2
화학식: C₁₈H₁₄F₆N₆O₂
분자량:460.33

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

WO677 Chemical Structure

CAS No.: 3088105-77-2

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

WO677 is a KCNT1 inhibitor that can be used in studies of nervous system disorders associated with KCNT1 function, such as epilepsy^[1].

In Vitro

WO677 (I‑1a) exhibits an IC₅₀ ≤ 250 nM in the FLIPR calcium flux inhibition assay^[1].
WO677 can be obtained via trifluoroacetic acid treatment, palladium-catalyzed C-N coupling, titanium-mediated imine formation, and diastereomeric intermediate conversion^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3088105-77-2
분자량 460.33
화학식 C₁₈H₁₄F₆N₆O₂
SMILES

CN1N=C(C(F)(F)F)C=C1C(N[C@H]2COCC3=NN(C4=CC(C(F)(F)F)=NC=C4)C=C32)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Stock N S. Heterocyclic compounds useful as kcnt1 inhibitors. WO2025117677A1, WIPO, 2025.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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