(Z)-Corallopyronin A
(Z)-Corallopyronin A is an isomer of Corallopyronin A (HY-N11622). Corallopyronin A is a polyketide natural product derived from myxobacteria and acts as a bacterial RNA polymerase (RNAP) inhibitor with antibacterial activity. Corallopyronin A binds to the switch region of RNA polymerase and allosterically blocks the transcription initiation process. Corallopyronin A exhibits in vitro antibacterial activity against Staphylococcus aureus, coagulase-negative staphylococci, Neisseria gonorrhoeae, and the filarial endosymbiont Wolbachia. (Z)-Corallopyronin A can be used for research related to bacterial infections.
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- CAS No.: 96789-48-9
- 화학식: C30H41NO7
- 분자량:527.65
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
RNA Polymerase |
In Vitro
(Z)-Corallopyronin A is an isomer of Corallopyronin A (HY-N11622). Corallopyronin A (0.06-16 μg/mL; 24 h) inhibits the growth of laboratory strains and clinical isolates of Neisseria gonorrhoeae, with MICs ranging from 0.125-1.0 μg/mL[1].
(Z)-Corallopyronin A is an isomer of Corallopyronin A (HY-N11622). Corallopyronin A (0.25-8 μg/mL; 24-48 h) eradicates intracellular live Neisseria gonorrhoeae parasitizing primary human cervical epithelial (Pex) cells without obvious cytotoxicity to host cells[1].
(Z)-Corallopyronin A is an isomer of Corallopyronin A (HY-N11622). Corallopyronin A (4-8 μg/mL; 24-48 h) inhibits biofilm formation by multidrug-resistant Neisseria gonorrhoeae on biotic and abiotic surfaces and disrupts established mature biofilm structures[1].
(Z)-Corallopyronin A is an isomer of Corallopyronin A (HY-N11622). Corallopyronin A (0.125-2 mg/L; 24 h) inhibits the growth of 116 staphylococcal isolates (including MRSA, MSSA, and CNS), with MIC90 = 0.5 mg/L for S. aureus and MIC90 = 1 mg/L for CNS[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 96789-48-9
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분자량 527.65
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화학식 C30H41NO7
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SMILES
C/C=C/C/C=C(C)\[C@H](O)CC/C(C)=C\C=C(C)\C(C1=C(C=C(OC1=O)[C@H](C)CC/C=C/NC(OC)=O)O)=O
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Structure Classification
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Initial Source
Corallococcus coralloides B035
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Z)-Corallopyronin A Related Classifications
HY-N21895 Related Classifications
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Keywords
- (Z)-Corallopyronin A
- 96789-48-9
- Drug Isomer
- Endogenous Metabolite
- Bacterial
- DNA/RNA Synthesis
- staphylococci
- biofilm formation
- MRSA
- Wolbachia endobacteria
- filarial nematodes
- bacterial RNA polymerase (RNAP) inhibitor
- switch region of the β-subunit
- Neisseria gonorrhoeae
- primary human cervical epithelial cells
- MtrCDE multidrug efflux pump
- Inhibitor
- inhibitor
- inhibit