96789-48-9
Chemical Structure
(Z)-Corallopyronin A
- CAS No.: 96789-48-9
- Formula:C30H41NO7
- Molecular Weight:527.65
InChIKey: FPBHSTHTCPCNBS-KLVYFJPZSA-N
SMILES: C/C=C/C/C=C(C)\[C@H](O)CC/C(C)=C\C=C(C)\C(C1=C(C=C(OC1=O)[C@H](C)CC/C=C/NC(OC)=O)O)=O
Biological Activity: (Z)-Corallopyronin A is an isomer of Corallopyronin A (HY-N11622). Corallopyronin A is a polyketide natural product derived from myxobacteria and acts as a bacterial RNA polymerase (RNAP) inhibitor with antibacterial activity. Corallopyronin A binds to the switch region of RNA polymerase and allosterically blocks the transcription initiation process. Corallopyronin A exhibits in vitro antibacterial activity against Staphylococcus aureus, coagulase-negative staphylococci, Neisseria gonorrhoeae, and the filarial endosymbiont Wolbachia. (Z)-Corallopyronin A can be used for research related to bacterial infections[1][2][3].
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(Z)-Corallopyronin A | (Z)-Corallopyronin A is an isomer of Corallopyronin A (HY-N11622). Corallopyronin A is a polyketide natural product derived from myxobacteria and acts as a bacterial RNA polymerase (RNAP) inhibitor with antibacterial activity. Corallopyronin A binds to the switch region of RNA polymerase and allosterically blocks the transcription initiation process. Corallopyronin A exhibits in vitro antibacterial activity against Staphylococcus aureus, coagulase-negative staphylococci, Neisseria gonorrhoeae, and the filarial endosymbiont Wolbachia. (Z)-Corallopyronin A can be used for research related to bacterial infections. | |||||||||||||||||||||
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References
- [1]. Edwards J L, et al. Potent In Vitro and Ex Vivo Anti‑Gonococcal Activity of the RpoB Inhibitor Corallopyronin A. mSphere, 2022, 7(5): e00362‑22.
- [2]. Schäberle TF, et al. Corallopyronin A - a promising antibiotic for treatment of filariasis. International journal of medical microbiology : IJMM. 2014 Jan;304(1):72-8.
- [3]. Karačić J, et al. Corallopyronin A exhibits potent activity against staphylococci including MRSA and isolates from prosthetic infections. Infection. 2026 Jun;54(3):1369-1381.
