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Cat. No.: HY-N21895

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(Z)-Corallopyronin A

(Z)-Corallopyronin A is an isomer of Corallopyronin A (HY-N11622). Corallopyronin A is a polyketide natural product derived from myxobacteria and acts as a bacterial RNA polymerase (RNAP) inhibitor with antibacterial activity. Corallopyronin A binds to the switch region of RNA polymerase and allosterically blocks the transcription initiation process. Corallopyronin A exhibits in vitro antibacterial activity against Staphylococcus aureus, coagulase-negative staphylococci, Neisseria gonorrhoeae, and the filarial endosymbiont Wolbachia. (Z)-Corallopyronin A can be used for research related to bacterial infections.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 96789-48-9
Formule: C₃₀H₄₁NO₇
Masse moléculaire:527.65

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(Z)-Corallopyronin A Chemical Structure

CAS No.: 96789-48-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

^[1]

RNA Polymerase

Voir tous les produits spécifiques à Isoform Endogenous Metabolite :

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis :

In Vitro

Bacterial Infection

(Z)-Corallopyronin A is an isomer of Corallopyronin A (HY-N11622). Corallopyronin A (0.06-16 μg/mL; 24 h) inhibits the growth of laboratory strains and clinical isolates of Neisseria gonorrhoeae, with MICs ranging from 0.125-1.0 μg/mL^[1].
(Z)-Corallopyronin A is an isomer of Corallopyronin A (HY-N11622). Corallopyronin A (0.25-8 μg/mL; 24-48 h) eradicates intracellular live Neisseria gonorrhoeae parasitizing primary human cervical epithelial (Pex) cells without obvious cytotoxicity to host cells^[1].
(Z)-Corallopyronin A is an isomer of Corallopyronin A (HY-N11622). Corallopyronin A (4-8 μg/mL; 24-48 h) inhibits biofilm formation by multidrug-resistant Neisseria gonorrhoeae on biotic and abiotic surfaces and disrupts established mature biofilm structures^[1].
(Z)-Corallopyronin A is an isomer of Corallopyronin A (HY-N11622). Corallopyronin A (0.125-2 mg/L; 24 h) inhibits the growth of 116 staphylococcal isolates (including MRSA, MSSA, and CNS), with MIC₉₀ = 0.5 mg/L for S. aureus and MIC₉₀ = 1 mg/L for CNS^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Bacterial Infection

(Z)-Corallopyronin A is an isomer of Corallopyronin A (HY-N11622). Corallopyronin A (35 mg/kg/day; i.p.; daily; 28 days) effectively clears Wolbachia endosymbionts and blocks parasite development in L. sigmodontis-infected mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 96789-48-9
Masse moléculaire 527.65
Formule C₃₀H₄₁NO₇
SMILES

C/C=C/C/C=C(C)\[C@H](O)CC/C(C)=C\C=C(C)\C(C1=C(C=C(OC1=O)[C@H](C)CC/C=C/NC(OC)=O)O)=O
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
- Microorganism
Corallococcus coralloides B035
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Edwards J L, et al. Potent In Vitro and Ex Vivo Anti‑Gonococcal Activity of the RpoB Inhibitor Corallopyronin A. mSphere, 2022, 7(5): e00362‑22.

[2]. Schäberle TF, et al. Corallopyronin A - a promising antibiotic for treatment of filariasis. International journal of medical microbiology : IJMM. 2014 Jan;304(1):72-8.

[3]. Karačić J, et al. Corallopyronin A exhibits potent activity against staphylococci including MRSA and isolates from prosthetic infections. Infection. 2026 Jun;54(3):1369-1381.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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