Lck Inhibitor III free base
Based on 1 Customer Validation
Lck Inhibitor III free base is a Lck inhibitor with an IC50 of 867 nM. Lck Inhibitor III free base inhibits the production of interleukin-2 (IL-2). Lck Inhibitor III free base can be used in the study of autoimmune diseases.
For research use only. We do not sell to patients.
- CAS No.: 918870-44-7
- Formula: C25H28N6O3
- Molecular Weight:460.53
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
Lck 867 nM (IC50) |
IL-2 1.270 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | IC50 |
1.270 μM
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Inhibition of IL-2 production in Jurkat cells.
Inhibition of IL-2 production in Jurkat cells.
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16997556 |
In Vitro
Lck Inhibitor III free base (Compound 12h) inhibits purified lymphocyte-specific kinase (Lck) with an IC50 of 867 nM[1].
The intrinsic clearance of Lck Inhibitor III free base (1 μM; 1 h) in cryopreserved rat hepatocyte suspensions is 48 mL/min kg[1].
Lck Inhibitor III free base inhibits IL-2 production in Jurkat cells with an IC50 of 1.270 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 918870-44-7
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Appearance Solid
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Molecular Weight 460.53
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Formula C25H28N6O3
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SMILES
COC1=CC=C(C)C(NC2=NC(N3C=NC4=C3C=CC=C4)=NC(OCCN5CCOCC5)=C2)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (217.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1714 mL | 10.8571 mL | 21.7141 mL | 54.2853 mL |
| 5 mM | 0.4343 mL | 2.1714 mL | 4.3428 mL | 10.8571 mL | |
| 10 mM | 0.2171 mL | 1.0857 mL | 2.1714 mL | 5.4285 mL | |
| 15 mM | 0.1448 mL | 0.7238 mL | 1.4476 mL | 3.6190 mL | |
| 20 mM | 0.1086 mL | 0.5429 mL | 1.0857 mL | 2.7143 mL | |
| 25 mM | 0.0869 mL | 0.4343 mL | 0.8686 mL | 2.1714 mL | |
| 30 mM | 0.0724 mL | 0.3619 mL | 0.7238 mL | 1.8095 mL | |
| 40 mM | 0.0543 mL | 0.2714 mL | 0.5429 mL | 1.3571 mL | |
| 50 mM | 0.0434 mL | 0.2171 mL | 0.4343 mL | 1.0857 mL | |
| 60 mM | 0.0362 mL | 0.1810 mL | 0.3619 mL | 0.9048 mL | |
| 80 mM | 0.0271 mL | 0.1357 mL | 0.2714 mL | 0.6786 mL | |
| 100 mM | 0.0217 mL | 0.1086 mL | 0.2171 mL | 0.5429 mL |
Lck Inhibitor III free base Related Classifications
HY-112335A Related Classifications
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