Octadecanoids

9(S),10(S),11(R)-Trihydroxy-12(Z)-octadecenoic acid is an ester product.

13(S)-Hydroxy-6(Z),9(Z),11(E)-octadecatrienoic acid is an ester product.

9-Hydroxy-10-oxo-12(Z)-octadecenoic acid ((Z)-9-Hydroxy-10-oxooctadec-12-enoic acid) is an ester product.

9-Hydroperoxy-10(E),12(E)-octadecadienoic acid ((10E,12E)-9-Hydroperoxyoctadeca-10,12-dienoic acid) is an ester product.

Dinor-12-oxo phytodienoic acid (2,3-Dinor-12-oxo-10,15(Z)-phytodienoic acid) is an ester product.

13 (S)-HOTrE is an oxylipin metabolite of α-Linolenic acid (HY-N0728). 13 (S)-HOTrE mediates the inactivation of the NLRP3 inflammasome through the PPAR-γ pathway to exert anti-inflammatory effects. 13 (S)-HOTrE inhibits NF-κB nuclear translocation, ROS production, autophagy and IL-1β levels, induces apoptosis, and increases IL-10 levels. 13 (S)-HOTrE alleviates LPS-induced inflammatory responses in macrophages, prolongs the survival time of septic mice, and regulates the immunometabolic phenotype in parenteral nutrition mouse models. 13 (S)-HOTrE can be used in the research of immune and inflammation-related diseases.

12-Oxo-octadecanoic acid (12-Oxo stearic acid) is an ester product.

cis-12,13-Epoxy-9(Z)-octadecenoic acid is an ester product.

cis-6,7-Epoxy-octadecanoic acid is an ester product.

12-Oxo-9(Z)-octadecenoic acid is an ester product.

10-Hydroxy-8(E),12(Z)-octadecadienoic acid is an ester product.

8(R)-Hydroxyoctadecanoic acid is an ester product.

8-Hydroxyoctadecanoic acid is an ester product.

9-Hydroxy-10(E),12(E)-octadecadienoic acid ((10E,12E)-9-Hydroxyoctadeca-10,12-dienoic acid) is an ester product.

(±)-10-Hydroxy-12(Z),15(Z)-octadecadienoic acid is a fatty acid derivative. (±)-10-Hydroxy-12(Z),15(Z)-octadecadienoic acid can be used in the food, cosmetic and pharmaceutical industries, such as starting materials for biodegradable polymers, lubricants, emulsifiers, drugs and fragrances.

4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of Docosahexaenoic acid (HY-B2167) with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 μM, however it increased proliferation of MCF-7 cells. 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and in dendritic cells with EC₅₀ values of approximately 8-16 μM.

9(E),12(Z)-Octadecadienoic acid is an ω-6 polyunsaturated fatty acid and an isomer of linoleic acid (HY-N0729) that contains a trans double bond at the C9 position. It has been found as a minor component of bovine milk fat and in partially hydrogenated vegetable oils. 9(E),12(Z)-Octadecadienoic acid levels increase in rabbit meat following supplementation with heated sunflower oil, α-tocopheryl acetate, and zinc.

cis-13-Octadecenoic acid is a monounsaturated fatty acid that has been found in bovine milk fat.

cis-8-Octadecenoic acid is a monounsaturated fatty acid and an isomer of oleic acid (HY-N1446), trans-vaccenic acid (HY-113427), trans-petroselinic acid, and cis-petroselinic acid. It has been found in partially hydrogenated vegetable oil and milk fat.

13(R)-HODE is the opposite enantiomer of the 13(S)-HODE produced when linoleic acid is incubated with soybean lipoxygenase. The presence of 13(R)-HODE in the supernatants and membranes of cultured bovine endothelial cells has been attributed to COX metabolism.1 13(R)-HODE is a weak (IC₅₀=2.7 μM) inhibitor of U-46619-induced platelet aggregation.