1. Apoptosis
  2. Ferroptosis
  3. Liproxstatin-1 hydrochloride

Liproxstatin-1 hydrochloride 

Cat. No.: HY-12726A
Handling Instructions

Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM).

For research use only. We do not sell to patients.

Liproxstatin-1 hydrochloride Chemical Structure

Liproxstatin-1 hydrochloride Chemical Structure

CAS No. : 2250025-95-5

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Top Publications Citing Use of Products

    Liproxstatin-1 hydrochloride purchased from MCE. Usage Cited in: Biochem Biophys Res Commun. 2019 Nov 5;519(2):240-245.

    The ROS and inflammatory cytokines levels increase in acute RILI. The serum levels of inflammatory cytokines increase in RILI. Elisa was used to measure the levels of inflammatory cytokines (TNF-a, IL-6, IL-10 and TGF-b1) at day 15, day 30 and day 60.
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    Description

    Liproxstatin-1 hydrochloride is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM)[1].

    In Vitro

    Liproxstatin-1 shows antiferroptotic activity with an IC50 of approximately 38 nM in mouse embryonic fibroblasts[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Liproxstatin-1 (10 mg/kg, i.p.) suppresses ferroptosis in human cells, Gpx4-/- kidney and in an ischaemia/reperfusion-induced tissue injury model[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    377.31

    Formula

    C₁₉H₂₂Cl₂N₄

    CAS No.
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
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    Product Name:
    Liproxstatin-1 hydrochloride
    Cat. No.:
    HY-12726A
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