2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Lurtotecan

Lurtotecan (GI147211; OSI-211), a semisynthetic Camptothecin analog, is a topoisomerase I inhibitor. Lurtotecan has anticancer effects.

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Lurtotecan

Lurtotecan Estructura química

No. CAS : 149882-10-0

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Lurtotecan Related Antibodies

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Topoisomerase Topo I Topo II DNA gyrase

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Descripciòn

Lurtotecan (GI147211; OSI-211), a semisynthetic Camptothecin analog, is a topoisomerase I inhibitor. Lurtotecan has anticancer effects[1].

IC50 & Target[1]

Topoisomerase I

 

Ensayo clínico
Peso molecular

518.56

Fòrmula

C28H30N4O6
No. CAS
Appearance

Solid

Color

White to yellow

SMILES

O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C(CN5CCN(C)CC5)C6=CC(OCCO7)=C7C=C6N=C4C3=C2)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvente y solubilidad
In Vitro: 

H2O : 10 mg/mL (19.28 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9284 mL 9.6421 mL 19.2842 mL
5 mM 0.3857 mL 1.9284 mL 3.8568 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.9284 mL 9.6421 mL 19.2842 mL 48.2104 mL
5 mM 0.3857 mL 1.9284 mL 3.8568 mL 9.6421 mL
10 mM 0.1928 mL 0.9642 mL 1.9284 mL 4.8210 mL
15 mM 0.1286 mL 0.6428 mL 1.2856 mL 3.2140 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Lurtotecan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lurtotecan149882-10-0GI147211 OSI-211GI 147211GI-147211OSI211OSI 211OSI-211TopoisomeraseCamptothecin analoganticancer effectsInhibitorinhibitorinhibit

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Nombre del producto:
Lurtotecan
Cat. No.:
HY-13670
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