Malformin C
Malformin C is an algicidal peptide can be isolated from Aspergillus and exhibits dose-dependent algicidal activity. Malformin C induces a significant increase in ROS levels in algal cells, resulting in impaired SOD activity and high production of MDA content.
For research use only. We do not sell to patients.
- CAS No.: 59926-78-2
- Formula: C23H39N5O5S2
- Molecular Weight:529.72
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
>10 μM
Compound: GNF-Pf-3267
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NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
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[PMID: 18579783] |
| TZM | CC50 |
16.4 μM
Compound: 5
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Cytotoxicity against human TZM-bl cells after 2 days by colorimetric XTT assay
Cytotoxicity against human TZM-bl cells after 2 days by colorimetric XTT assay
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[PMID: 26711143] |
Chemical Information
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CAS No. 59926-78-2
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Molecular Weight 529.72
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Formula C23H39N5O5S2
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Sequence
Cyclo({d-Cys}-{d-Cys}-Val-{d-Leu}-Leu) (Disulfide bridge: Cys1-Cys2)
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Sequence Shortening
Cyclo({d-Cys}-{d-Cys}-V-{d-Leu}-L) (Disulfide bridge: Cys1-Cys2)
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Structure Classification
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Initial Source
Aspergillus sp
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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ROS/oxidative-stress fluorescent staining
ROS/oxidative-stress fluorescent staining uses cell-permeant fluorogenic probes that become fluorescent after oxidation inside cells or tissues; commonly used examples include DCFH-DA/DCFDA for broad cellular oxidant detection, DHE for superoxide-related signal detection, MitoSOX for mitochondrial superoxide-related signal detection, and CellROX probes for oxidative-stress-associated fluorescence readouts. The assay detects probe oxidation rather than a single ROS species unless the probe and analysis method have been chemically validated for that species. DCFH-DA enters cells, is deacetylated by intracellular esterases to DCFH, and produces fluorescent DCF after oxidation, so the readout is used as an operational measure of total cellular oxidative stress rather than a species-specific ROS measurement. DHE and MitoSOX can report superoxide-related oxidation, but red fluorescence alone can include non-specific ethidium-like oxidation products; HPLC or optimized spectral approaches are
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Malformin C Related Classifications
HY-P2005 Related Classifications
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